Experimental Medications Made with Сetraria islandica Showing Antiviral Activity against Influenza A Virus

Antibiotics and Chemotherapy Pub Date : 2024-01-15 DOI:10.37489/0235-2990-2023-68-9-10-12-19

E. V. Makarevich, M. Protsenko, O. Mazurkov, E. Filippova, N. Mazurkova

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Abstract

Background. To date, virologists have identified more than 25,000 influenza virus А serotypes, and their number will increase in the future. Therefore, the development of new antiviral drugs will always be relevant.The aim of the study is to obtain and test the chemical composition and antiviral activity of the lichen Cetraria islandica extracts against the influenza A virus.Material and methods. Samples of lichen Cetraria islandica (aqueous and ethanol extracts) were tested for toxic properties and antiviral activity against influenza A virus in MDCK cell culture.Results. Samples of aqueous and ethanol extracts of Cetraria islandica were obtained; their chemical composition was described. In MDCK cell culture, the extracts exhibited antiviral activity against human influenza virus А/H3N2 and avian influenza virus А/H5N1. When studying the mechanism of action of Cetraria islandica extracts, it was noted that Cetraria islandica samples possess pronounced antiviral properties against avian influenza A/chicken/Kurgan/05/2005 (H5N1) and human influenza A/Aichi/2/68 (H3N2) at the stage of their adsorption and reproduction.Conclusions. Samples of Cetraria islandica have antiviral activity at the stage of adsorption and reproduction of influenza A virus in MDCK cell culture. The ethanol extract shows a higher antiviral efficacy compared to the aqueous extract.

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用岛茨藻制成的实验性药物对甲型流感病毒具有抗病毒活性

背景。迄今为止，病毒学家已经发现了超过 25000 种流感病毒 А 血清型，未来其数量还会增加。因此，开发新的抗病毒药物将始终具有现实意义。本研究的目的是获得并测试地衣 Cetraria islandica 提取物的化学成分和对甲型流感病毒的抗病毒活性。在 MDCK 细胞培养中测试了地衣（水提取物和乙醇提取物）的毒性和对甲型流感病毒的抗病毒活性。获得了 Cetraria islandica 的水提取物和乙醇提取物样本，并描述了它们的化学成分。在 MDCK 细胞培养中，提取物对人流感病毒 А/H3N2 和禽流感病毒 А/H5N1 具有抗病毒活性。在研究岛链蕨提取物的作用机制时，发现岛链蕨样本在吸附和繁殖阶段对禽流感 A/鸡/Kurgan/05/2005（H5N1）和人流感 A/Aichi/2/68（H3N2）具有明显的抗病毒特性。Cetraria islandica 样品在 MDCK 细胞培养中对甲型流感病毒的吸附和繁殖阶段具有抗病毒活性。乙醇提取物的抗病毒效力高于水提取物。

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Antibiotics and Chemotherapy

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