Polypragmasy and the basics of personalized rational pharmacotherapy selection in older patients with obesity and type 2 diabetes mellitus

Q3 Medicine

Obesity and Metabolism Pub Date : 2024-01-22 DOI:10.14341/omet12987

E. A. Troshina, V. O. Barysheva, Z-Sh. R. Umarkhadzhieva

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引用次数: 0

Abstract

Increasing life expectancy and, as a consequence, a large number of comorbidities lead to a multitude of medications prescribed by physicians of different specialties. Patients with obesity and carbohydrate metabolism disorders, especially with type 2 diabetes mellitus (DM2), are at particular risk of polypragmasy, which is associated with the use of potentially nonrecommended medications. Prescribing errors can cause significant harm to the patient’s health and increase the risk of rehospitalization and healthcare costs. Identification of probably not recommended drugs in this category of patients will improve understanding of prevalence and risk factors of their use, develop strategies to prevent and limit the burden of taking inappropriate drugs and promote development of personalized and patient-oriented treatment options. Tools exist to assess potentially inappropriate therapy (PIT) in the elderly and new tools and criteria are often created. However, they are not specifically aimed at people with obesity and carbohydrate metabolism disorders. Thus, these criteria usually include only a few items related to DM2. Consequently, there is a clear need for a modern tool that can be used to address PIT specifically in older adults with obesity and carbohydrate metabolism disorders.

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老年肥胖症和 2 型糖尿病患者的多膈畸形和个性化合理药物治疗选择的基础知识

人们的寿命越来越长，因此合并症也越来越多，导致不同专业的医生开出的处方药也越来越多。肥胖症和碳水化合物代谢紊乱的患者，尤其是 2 型糖尿病（DM2）患者，尤其容易出现多药方的情况，这与使用可能不推荐的药物有关。处方错误会对患者的健康造成重大损害，并增加再次住院的风险和医疗成本。识别这类患者中可能未被推荐的药物将有助于更好地了解其使用的普遍性和风险因素，制定预防和限制服用不适当药物所造成的负担的策略，并促进以患者为导向的个性化治疗方案的开发。目前已有一些工具可用于评估老年人潜在的不恰当治疗（PIT），新的工具和标准也在不断涌现。然而，这些工具和标准并非专门针对肥胖和碳水化合物代谢紊乱患者。因此，这些标准通常只包括几个与 DM2 有关的项目。因此，我们显然需要一种现代工具，专门用于解决肥胖和碳水化合物代谢紊乱老年人的 PIT 问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity and Metabolism Medicine-Internal Medicine

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Journal "Obesity and Metabolism" is a multidisciplinary forum for clinical and applied research in the field of biochemistry, physiology, pathophysiology, genetics, nutrition, as well as molecular, metabolic, psychological and epidemiological aspects of obesity and metabolism. The main subject "Metabolism" reviewed in the journal, includes fat, carbohydrate, protein, bone, fluid and electrolyte and other types of metabolism in the spectrum of pathology of the endocrine system. The priority direction of Journal "Obesity and Metabolism" is publishing modern high-quality original research on the effectiveness of new and existing treatments in any aspect of metabolic and endocrine diseases. Pre-clinical pharmacology, pharmacokinetics studies, meta-analyzes, addressed to drug safety and tolerance are also welcome for publication in the journal "Obesity and metabolism." Journal "Obesity and Metabolism" announces review articles that are balanced, clear and offer the reader a modern and critical analysis of the literature on the subject of the magazine. Case reports, and lecture materials are also published for highlighting for practitioners new approaches to diagnosis and treatment of patients with metabolic disorders and obesity.