Impact of Topical Capsaicin Cream on Thermoregulation and Perception While Walking in the Cold

Alejandro M. Rosales, Jessica L. Moler, Andrew C. Engellant, Alice L. Held, Dustin R. Slivka
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Abstract

Capsaicin, a chili pepper extract, can stimulate increased skin blood flow (SkBF) with a perceived warming sensation on application areas. Larger surface area application may exert a more systemic thermoregulatory response. Capsaicin could assist with maintaining heat transport to the distal extremities, minimizing cold weather injury risk. However, the thermoregulatory and perceptual impact of topical capsaicin cream application prior to exercise in the cold is unknown. Following application of either a 0.1% capsaicin or control cream to the upper and lower extremities (10 g total, ∼40–50% body surface area), 11 participants in shorts and a t-shirt were exposed to 30 min of cold (0 °C, 40% relative humidity). Exposures comprised of 5 min seated rest, 20 min walking (1.6 m·s−1, 5% grade), and 5 min seated rest. Temperature (skin, core), SkBF, skin conductivity, heart rate, thermal sensation, and thermal comfort were measured throughout. The capsaicin treatment did not differ from the control treatment in skin temperature (treatment mean: 30.0 ± 2.5, 30.1 ± 2.4 °C, respectively, p = 0.655), core temperature (treatment mean: 37.3 ± 0.5, 37.4 ± 0.4 °C, respectively, p = 0.113), SkBF (treatment mean: −8.4 ± 10.0, −11.1 ± 10.7 A.U., respectively, p = 0.492), skin conductivity (treatment mean: −0.7 ± 5.1, 0.4 ± 6.4 µS, respectively, p = 0.651), or heart rate (treatment mean: 83 ± 29, 85 ± 28 beats·minute−1, respectively, p = 0.234). The capsaicin and control treatments also did not differ in thermal sensation ( p = 0.521) and thermal comfort ( p = 0.982), with perceptual outcomes corresponding with feeling “cool” and “just uncomfortable,” respectively. 0.1% topical capsaicin application to exposed limbs prior to walking in a cold environment does not alter whole-body thermoregulation or thermal perception.
在寒冷中行走时,外用辣椒素霜对体温调节和感知的影响
辣椒素是一种辣椒提取物,可刺激皮肤血流量(SkBF)增加,并使涂抹部位产生温暖的感觉。更大面积的涂抹可能会产生更系统的体温调节反应。辣椒素可以帮助维持肢体远端热量运输,最大限度地降低寒冷天气中的受伤风险。然而,在寒冷环境中运动前局部涂抹辣椒素软膏对体温调节和感知的影响尚不清楚。在上肢和下肢涂抹 0.1% 的辣椒素乳膏或对照组乳膏(共 10 克,占体表面积的 40-50% 左右)后,11 名身着短裤和 T 恤的参与者暴露在 30 分钟的寒冷环境中(0 °C,相对湿度 40%)。暴露过程包括 5 分钟坐姿休息、20 分钟步行(1.6 米-秒-1,5%坡度)和 5 分钟坐姿休息。对体温(皮肤、核心)、SkBF、皮肤电导率、心率、热感觉和热舒适度进行了全程测量。辣椒素处理与对照组处理在皮肤温度(处理平均值:分别为 30.0 ± 2.5 和 30.1 ± 2.4 °C,p = 0.655)、核心温度(处理平均值:分别为 37.3 ± 0.5 和 37.4 ± 0.4 °C,p = 0.113)、SkBF(处理平均值:分别为 -8.4 ± 10.0 和 -11.1 ± 10.7 A.U.,p = 0.492)和心率(处理平均值:分别为 -8.4 ± 10.0 和 -11.1 ± 10.7 A.U.,p = 0.492)方面没有差异、分别为-8.4 ± 10.0、-11.1 ± 10.7 A.U,p = 0.492)、皮肤电导率(处理平均值:-0.7 ± 5.1、0.4 ± 6.4 µS,分别为 p = 0.651)或心率(处理平均值:83 ± 29、85 ± 28 次/分钟-1,分别为 p = 0.234)。辣椒素治疗和对照组治疗在热感觉(p = 0.521)和热舒适度(p = 0.982)方面也没有差异,感知结果分别是感觉 "凉爽 "和 "只是不舒服"。在寒冷环境中行走前在暴露的肢体上局部涂抹 0.1% 的辣椒素不会改变全身的体温调节或热感觉。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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