Vitamin D metabolism in diabetic nephropathy

Q3 Medicine

Obesity and Metabolism Pub Date : 2024-01-22 DOI:10.14341/omet12943

Z. V. Abilov, R. Salimkhanov, A. Povaliaeva, A. Zhukov, E. Pigarova, L. K. Dzeranova, L. Rozhinskaya

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引用次数: 0

Abstract

Diabetic nephropathy (DN) is a specific kidney involvement in diabetes mellitus (DM), caused by hemodynamic and metabolic factors. In the kidneys takes place an important step in the metabolism of vitamin D — 1α-hydroxylation, which results in the formation of its biologically active form. Reduced number of functioning nephrons in DN leads to impaired vitamin D metabolism, contributing to the development of a number of complications. In this review, we have focused in detail on both normal vitamin D metabolism and the features of vitamin D metabolism in chronic kidney disease (CKD). DN is the most common cause of CKD and, as a consequence, of kidney transplantation and one of the leading causes of cardiovascular morbidity and mortality in patients with DM. Bone mineral disorders resulting from abnormal vitamin D metabolism are also independent factors of high mortality among patients with DM. The final part of our review briefly highlights current approaches to vitamin D therapy in CKD and, in particular, in DN. It is worth noting that, despite the increasing number of patients with DN, there is currently no unified view on the use of vitamin D as a therapeutic agent in this pathology.

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糖尿病肾病中的维生素 D 代谢

糖尿病肾病（DN）是糖尿病（DM）的一种特殊肾脏病变，由血液动力学和代谢因素引起。在肾脏中进行维生素 D 代谢的一个重要步骤是 1α- 羟基化，从而形成其生物活性形式。DN 患者肾小球功能的减少导致维生素 D 代谢受损，从而引发一系列并发症。在这篇综述中，我们重点详细介绍了正常的维生素 D 代谢和慢性肾脏病（CKD）中维生素 D 代谢的特点。DN 是导致 CKD 的最常见原因，也是肾移植的最常见原因，同时还是 DM 患者心血管疾病发病率和死亡率的主要原因之一。维生素 D 代谢异常导致的骨矿物质紊乱也是导致糖尿病患者高死亡率的独立因素。综述的最后一部分简要介绍了目前针对 CKD，尤其是 DN 的维生素 D 治疗方法。值得注意的是，尽管 DN 患者的人数在不断增加，但目前对于将维生素 D 用作该病症的治疗药物还没有统一的看法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity and Metabolism Medicine-Internal Medicine

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Journal "Obesity and Metabolism" is a multidisciplinary forum for clinical and applied research in the field of biochemistry, physiology, pathophysiology, genetics, nutrition, as well as molecular, metabolic, psychological and epidemiological aspects of obesity and metabolism. The main subject "Metabolism" reviewed in the journal, includes fat, carbohydrate, protein, bone, fluid and electrolyte and other types of metabolism in the spectrum of pathology of the endocrine system. The priority direction of Journal "Obesity and Metabolism" is publishing modern high-quality original research on the effectiveness of new and existing treatments in any aspect of metabolic and endocrine diseases. Pre-clinical pharmacology, pharmacokinetics studies, meta-analyzes, addressed to drug safety and tolerance are also welcome for publication in the journal "Obesity and metabolism." Journal "Obesity and Metabolism" announces review articles that are balanced, clear and offer the reader a modern and critical analysis of the literature on the subject of the magazine. Case reports, and lecture materials are also published for highlighting for practitioners new approaches to diagnosis and treatment of patients with metabolic disorders and obesity.