PENGARUH SUPLEMENTASI KOMBINASI BAWANG PUTIH (ALLIUM SATIVUM), BERAS RAGI MERAH (MONASCUS PURPUREUS), DAN JAHE MERAH (ZINGIBER OFFICINALE VAR. RUBRUM) TERHADAP KADAR TRIGLISERIDA DAN HDL PASIEN STROKE ISKEMIK DENGAN DISLIPIDEMIA

Journal of Nutrition College Pub Date : 2024-01-23 DOI:10.14710/jnc.v13i1.42033

Rihadatul Aisy, Nani Maharani, Santoso Jaeri, Retnaningsih Retnaningsih

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Objectives: The purpose of this study was to determine the effect of giving herbs containing garlic (Allium sativum) 675 mg, red yeast rice (Monascus purpureus) 750 mg, and red ginger (zingiber officinale var. rubrum) 375 mg, hereinafter referred to as BJR 22 on TG and HDL levels.Materials and Methods: This research was pre and posttest Control Group Design with double blind method. The research subjects were selected consecutively with 20 intervention groups receiving standard therapy (statins) and BJR 22 3 capsules/day and 20 control groups receiving standard therapy (statins) and placebo once daily, each group being given for 30 days. The data were analyzed used the Shapiro wilk test, Wilcoxon, Chi Square, Fisher's exact and Paired T-test. Results: The average change in TG levels before and after treatment in the intervention group was -5.95 ± 86.88 (p=0.575), while the control group was 4.3 ± 97.08 (p=0.845). There was no significant difference between the two group. 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Abstract

ABSTRACTBackground: The incidence of stroke in the world is reported as many as 15 million people each year and around 185 thousand experience recurrent strokes. The incidence of recurrent stroke can be avoided by controlling risk factors, especially dyslipidemia. There is a relationship between dyslipidemia and the risk of atherosclerosis, especially ischemic stroke and peripheral arterial disease. Nutraceuticals can be used as an adjuvant to conventional drugs. Objectives: The purpose of this study was to determine the effect of giving herbs containing garlic (Allium sativum) 675 mg, red yeast rice (Monascus purpureus) 750 mg, and red ginger (zingiber officinale var. rubrum) 375 mg, hereinafter referred to as BJR 22 on TG and HDL levels.Materials and Methods: This research was pre and posttest Control Group Design with double blind method. The research subjects were selected consecutively with 20 intervention groups receiving standard therapy (statins) and BJR 22 3 capsules/day and 20 control groups receiving standard therapy (statins) and placebo once daily, each group being given for 30 days. The data were analyzed used the Shapiro wilk test, Wilcoxon, Chi Square, Fisher's exact and Paired T-test. Results: The average change in TG levels before and after treatment in the intervention group was -5.95 ± 86.88 (p=0.575), while the control group was 4.3 ± 97.08 (p=0.845). There was no significant difference between the two group. The change in HDL levels in the intervention group was 10 ± 13.46, indicating a significant change (p = 0.004). In the control group it was 5.3 ± 27.25 indicating a change that was not significant (p = 0.273). The regression test shows that the factors that influence TG levels are calorie intake and those that influence HDL levels are smoking status, hypertension and fat intake.Conclusion: BJR 22 supplementation of 3 capsules/day for 30 days can improve HDL levels but does not significantly affect triglyceride levels.Keywords: Garlic, Red Yeast Rice, Dyslipidemia, Red Ginger, Stroke ABSTRAKLatar belakang: Penderita stroke memiliki risiko serangan berulang sekitar 11,1 % dalam 1 tahun. Insiden stroke berulang dihindari dengan upaya pengendalian faktor risiko salah satunya dislipidemia. Terdapat hubungan dislipidemia dengan risiko kejadian aterosklerosis terutama penyakit stroke iskemik dan penyakit arteri perifer. Prevalensi penderita statin intoleran ada 9,1%. Nutrasetikal dapat digunakan sebagai terapi adjuvant/pendamping obat konvensional. Tujuan penelitian ini untuk mengetahui efek pemberian herbal yang mengandung bawang putih (Allium sativum) 675 mg, Red Yeast Rice (RYR)/beras ragi merah (Monascus purpureus) 750 mg, dan jahe merah (zingiber officinale var. rubrum) 375 mg yang selanjutnya disebut BJR 22 terhadap kadar trigliserida (TG) dan High Density Lipoprotein (HDL).Metode: Penelitian dengan menggunakan pre and posttest control group design dengan cara double blind. Subjek penelitian dipilih secara konsekutif dengan jumlah 20 orang dalam kelompok intervensi yang mendapatkan terapi standar (statin) dan BJR 22 sebanyak 3 kapsul/hari dan 20 orang dalam kelompok kontrol yang mendapatkan terapi standar (statin) dan plasebo 3x1. Durasi penelitian adalah 30 hari. Data dianalisis menggunakan uji Saphiro Wilk, Wilcoxon, Chi Square, Fisher exact dan Paired T-test.Hasil: Rata-rata perubahan kadar TG sebelum dan sesudah perlakuan di kelompok intervensi adalah -5,95 ± 86,88 mg/dL (p=0,575), sedangkan kelompok kontrol 4,3 ± 97,08 mg/dL (p=0.845) Tidak ada perbedaan signifikan antara kedua kelompok. Perubahan kadar HDL di kelompok intervensi adalah 10 ± 13,46 mg/dL menunjukkan perubahan yang bermakna (p=0,004). Pada kelompok kontrol adalah 5,3 ± 27,25 mg/dL menunjukkan perubahan yang tidak bermakna (p=0,273). Uji regresi menunjukkan faktor yang memengaruhi kadar TG adalah asupan kalori dan yang memengaruhi kadar HDL adalah status merokok, hipertensi dan asupan lemak.Kesimpulan: Suplementasi BJR 22 dosis 3 kapsul/hari dapat memperbaiki kadar HDL namun tidak mempengaruhi kadar trigliserida secara bermakna.Kata Kunci: Bawang putih, Beras Ragi Merah, Dislipidemia, Jahe merah, Stroke

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补充大蒜（薤白）、红麴（紫麴）和红姜（姜黄）对血脂异常的缺血性中风患者甘油三酯和高密度脂蛋白水平的影响

摘要背景：据报道，全世界每年的中风发病率高达 1500 万，约 18.5 万人经历过复发性中风。通过控制危险因素，尤其是血脂异常，可以避免复发性脑卒中的发生。血脂异常与动脉粥样硬化，尤其是缺血性中风和外周动脉疾病的风险之间存在关系。营养保健品可作为常规药物的辅助药物。研究目的本研究旨在确定服用含大蒜（Allium sativum）675 毫克、红曲米（Monascus purpureus）750 毫克和红姜（zingiber officinale var. rubrum）375 毫克（以下简称 BJR 22）的中草药对 TG 和 HDL 水平的影响：本研究采用前后对照组设计和双盲法。研究对象连续选取，20 个干预组接受标准疗法（他汀类药物）和 BJR 22，每天 3 粒；20 个对照组接受标准疗法（他汀类药物）和安慰剂，每天 1 次，每组 30 天。数据分析采用 Shapiro wilk 检验、Wilcoxon 检验、Chi Square 检验、费雪精确检验和配对 T 检验。结果干预组治疗前后 TG 水平的平均变化为 -5.95 ± 86.88（P=0.575），而对照组为 4.3 ± 97.08（P=0.845）。两组之间无明显差异。干预组的高密度脂蛋白水平变化为 10 ± 13.46，显示出显著变化（p = 0.004）。对照组为 5.3 ± 27.25，变化不明显（p = 0.273）。回归测试表明，影响 TG 水平的因素是卡路里摄入量，而影响 HDL 水平的因素是吸烟状况、高血压和脂肪摄入量：结论：连续 30 天每天补充 3 粒 BJR 22 可改善高密度脂蛋白水平，但对甘油三酯水平无明显影响：大蒜红麴血脂异常红姜中风 ABSTRAKLatar belakang：中风的发病率为 11.1%。中风的发病率与血脂异常有关。血脂异常可导致中风和动脉硬化。他汀类药物不耐受的患病率为 9.1%。他汀类药物不耐受的患病率为 9.1%。本品含有 675 毫克葱（Allium sativum）、750 毫克红曲米（Monascus purpureus）和 375 毫克姜黄（Zingiber officinale var.375 毫克，不含 BJR 22，可用于降低血脂（TG）和高密度脂蛋白（HDL）：方法：采用双盲对照组设计，进行前后对照试验。干预组有 20 人，他们接受标准治疗（他汀）和 BJR 22，每小时 3 次；对照组有 20 人，他们接受标准治疗（他汀）和 3x1 血浆。数据采用 Saphiro Wilk、Wilcoxon、Chi Square、Fisher exact 和配对 T 检验：干预组的血清总胆固醇平均值为 -5,95 ± 86,88 mg/dL (P=0,575)，对照组为 4,3 ± 97,08 mg/dL (P=0.845)。干预组的高密度脂蛋白平均值为 10 ± 13.46 毫克/分升，低于对照组（p=0.004）。而对照组为 5.3 ± 27.25 毫克/分升，表明干预者的血脂正常（p=0.273）。回归结果显示，TG 和 HDL 的变化趋势分别为高胆固醇、高胰岛素和高密度脂蛋白：补充 BJR 22，剂量为 3 kapsul/hari，可降低高密度脂蛋白的含量，同时也可降低三高症的发病率。

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Journal of Nutrition College

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