1,2,4-Triazole-conjugated Fluoroquinolones as Potential Candidates for New Antibacterial Agents

IF 0.7 4区化学 Q4 CHEMISTRY, ORGANIC

Letters in Organic Chemistry Pub Date : 2024-01-26 DOI:10.2174/0115701786270260231215101046

Yildiz Uygun Cebeci, Sengul Alpay Karaoglu

引用次数: 0

Abstract

: In this study, synthesis of 1,2,4 triazo1e-fluoroquino1one hybrid compounds was rea1ized. 7a-d hybrid compound was obtained as a result of mannich reaction with 6a-b triazole compounds norfloxacin and ciprofloxacin. 1H-NMR, 13C-NMR, Mass Spectrometry and Elemental Analysis confirmed the structures of a11 synthesized compounds. The antimicrobia1 activities of a11 compounds were investigated, and it was observed that 7a-d compounds, which are mannich bases, showed excellent activity.

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1,2,4-三唑共轭氟喹诺酮类药物作为新型抗菌剂的潜在候选药物

:本研究重新合成了 1,2,4 三氮唑-1e-氟喹酮杂化物。6a-b 三唑化合物诺氟沙星和环丙沙星通过曼尼希反应得到了 7a-d 杂化物。1H-NMR、13C-NMR、质谱和元素分析证实了 a11 个合成化合物的结构。对 a11 化合物的抗菌活性进行了研究，结果表明，7a-d 化合物（属于甘露聚糖碱）表现出极高的活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Letters in Organic Chemistry 化学-有机化学

CiteScore

1.30

自引率

12.50%

发文量

135

审稿时长

7 months

期刊介绍： Aims & Scope Letters in Organic Chemistry publishes original letters (short articles), research articles, mini-reviews and thematic issues based on mini-reviews and short articles, in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts. The journal is an essential reading for all organic chemists belonging to both academia and industry.