Sjögren's Disease and Oral Health: A Genetic Instrumental Variable Analysis.

Journal of dental research Pub Date : 2024-03-01 Epub Date: 2024-01-29 DOI:10.1177/00220345231218903
S L Reckelkamm, Z Alayash, B Holtfreter, M Nolde, S E Baumeister
{"title":"Sjögren's Disease and Oral Health: A Genetic Instrumental Variable Analysis.","authors":"S L Reckelkamm, Z Alayash, B Holtfreter, M Nolde, S E Baumeister","doi":"10.1177/00220345231218903","DOIUrl":null,"url":null,"abstract":"<p><p>Epidemiological studies have consistently shown that Sjögren's disease (SjD) increases the risk of dental caries. Despite similar evidence indicating an elevated risk of periodontitis, SjD remains a disputed risk factor for this disease. The risk of bias in observational research is a major impediment to confirming this link. Within an instrumental variable framework, genetic variants associated with a risk factor can be used to proxy its effect on an outcome while avoiding common sources of observational study bias. In this study, we leveraged an instrumental variable approach to investigate whether SjD affects the risk of caries and periodontitis. A total of 57 genetic variants strongly associated with SjD were identified from a genome-wide association study of 2,247 European descent cases and 332,115 controls. We tested for associations of these genetic instruments with caries (measured as the number of decayed, missing, and filled surfaces in 26,792 individuals) and periodontitis (17,353 clinical periodontitis cases and 28,210 European controls). Several sensitivity analyses were used to further validate the primary inverse variance weighted (IVW) estimate. IVW analysis revealed an adverse effect of SjD on caries (β = 0.039, <i>P</i> = 6.3e-16) and periodontitis (odds ratio = 1.033, <i>P</i> = 2.3e-05). Sensitivity analyses, conducted to assess the robustness to potential violations of instrumental variable assumptions, further support these findings. Our results showed that SjD has a detrimental effect on caries and also suggest that SjD promotes periodontitis.</p>","PeriodicalId":94075,"journal":{"name":"Journal of dental research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10900855/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of dental research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/00220345231218903","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/29 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Epidemiological studies have consistently shown that Sjögren's disease (SjD) increases the risk of dental caries. Despite similar evidence indicating an elevated risk of periodontitis, SjD remains a disputed risk factor for this disease. The risk of bias in observational research is a major impediment to confirming this link. Within an instrumental variable framework, genetic variants associated with a risk factor can be used to proxy its effect on an outcome while avoiding common sources of observational study bias. In this study, we leveraged an instrumental variable approach to investigate whether SjD affects the risk of caries and periodontitis. A total of 57 genetic variants strongly associated with SjD were identified from a genome-wide association study of 2,247 European descent cases and 332,115 controls. We tested for associations of these genetic instruments with caries (measured as the number of decayed, missing, and filled surfaces in 26,792 individuals) and periodontitis (17,353 clinical periodontitis cases and 28,210 European controls). Several sensitivity analyses were used to further validate the primary inverse variance weighted (IVW) estimate. IVW analysis revealed an adverse effect of SjD on caries (β = 0.039, P = 6.3e-16) and periodontitis (odds ratio = 1.033, P = 2.3e-05). Sensitivity analyses, conducted to assess the robustness to potential violations of instrumental variable assumptions, further support these findings. Our results showed that SjD has a detrimental effect on caries and also suggest that SjD promotes periodontitis.

斯约格伦病与口腔健康:遗传工具变量分析》。
流行病学研究一致表明,斯约格伦病(SjD)会增加龋齿的风险。尽管有类似的证据表明牙周炎的风险升高,但 SjD 仍然是一个有争议的风险因素。观察性研究中的偏倚风险是证实这种联系的主要障碍。在工具变量框架内,与风险因素相关的遗传变异可用于替代风险因素对结果的影响,同时避免观察性研究中常见的偏倚来源。在本研究中,我们利用工具变量方法研究了 SjD 是否会影响龋齿和牙周炎的风险。在对 2,247 例欧洲血统病例和 332,115 例对照进行的全基因组关联研究中,共发现了 57 个与 SjD 密切相关的遗传变异。我们检测了这些基因工具与龋齿(以 26,792 人的蛀蚀、缺失和填充表面的数量来衡量)和牙周炎(17,353 例临床牙周炎病例和 28,210 例欧洲对照)之间的关联。为了进一步验证主要的逆方差加权(IVW)估计值,我们进行了多项敏感性分析。IVW 分析显示,SjD 对龋齿(β = 0.039,P = 6.3e-16)和牙周炎(几率比 = 1.033,P = 2.3e-05)有不利影响。为评估可能违反工具变量假设的稳健性而进行的敏感性分析进一步支持了这些发现。我们的研究结果表明,SjD 对龋病有不利影响,同时也表明 SjD 会促进牙周炎。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信