Level of biochemical parameters in patients with type 2 diabetes mellitus depending on the genotype of the FokI polymorphism in the vitamin D3 receptor (VDR gene).

IF 1.1 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Central European journal of public health Pub Date : 2023-12-01 DOI:10.21101/cejph.a7837

Mária Konečná, Janka Poráčová, Melinda Nagy, Mária Majherová, Jana Gaľová, Zuzana Gogaľová, Hedviga Vašková, Marta Mydlárová Blaščáková, Daniela Gruľová, Vincent Sedlák

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引用次数: 0

Abstract

Objectives: Diabetes mellitus type 2 (T2DM) is a multifactorial and polygenic disorder characterised by chronic hyperglycaemia accompanied by impaired lipid, carbohydrate, and protein metabolism. The disease is associated with several genetic polymorphisms, including the FokI polymorphism in the vitamin D receptor (VDR) gene.

Methods: We conducted a study of 327 probands (191 T2DM patients, 136 controls), with a mean age 65.06 (SD ± 10.88) years of patients with T2DM and 58.89 (SD ± 6.59) years in the healthy probands. We investigated the association between FokI polymorphism and biochemical parameters in T2DM patients in the Slovak population. Anthropometric measurements, biochemical, and genetic analysis were statistically evaluated by Statistica ver.13 software using t-tests.

Results: Biochemical analysis confirmed significantly higher mean values of total cholesterol (TC), triglyceride (TG), glucose (GLU), and uric acid (UA) (p < 0.001) in T2DM probands and statistically significantly lower values of high-density lipoprotein (HDL), cholesterol and vitamin D (p < 0.001). Allele frequencies and genotype distributions of the FokI (rs2228570) polymorphism were not significantly different between T2DM patients and controls (p = 0.909). Patients with T2DM and TT genotype had the highest glucose level of 11.39 (SD ± 2.32) uU/ml (p < 0.001).

Conclusion: Our study did not provide evidence for an association of the investigated FokI polymorphism of the VDR gene with T2DM in the Slovak population. Further research is needed to evaluate the impact of single nucleotide polymorphisms (SNPs) in the VDR gene, focusing on related genetic analyses in a larger T2DM cohort.

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2 型糖尿病患者的生化指标水平取决于维生素 D3 受体（VDR 基因）的 FokI 多态性基因型。

目的：2 型糖尿病（T2DM）是一种多因素和多基因疾病，其特点是慢性高血糖，同时伴有脂质、碳水化合物和蛋白质代谢障碍。这种疾病与多种基因多态性有关，包括维生素 D 受体（VDR）基因中的 FokI 多态性：我们对 327 名原发性糖尿病患者（191 名 T2DM 患者，136 名对照组）进行了研究，其中 T2DM 患者的平均年龄为 65.06 岁（SD ± 10.88），健康原发性糖尿病患者的平均年龄为 58.89 岁（SD ± 6.59）。我们研究了斯洛伐克人群中 T2DM 患者的 FokI 多态性与生化指标之间的关系。我们使用 Statistica ver.13 软件对人体测量、生化和遗传分析进行了统计评估，并使用 t 检验：结果：生化分析证实，T2DM 患者的总胆固醇 (TC)、甘油三酯 (TG)、葡萄糖 (GLU) 和尿酸 (UA) 平均值明显升高（P < 0.001），而高密度脂蛋白 (HDL)、胆固醇和维生素 D 的平均值则明显降低（P < 0.001）。T2DM患者和对照组之间FokI（rs2228570）多态性的等位基因频率和基因型分布无明显差异（p = 0.909）。T2DM患者和TT基因型患者的血糖水平最高，为11.39 (SD ± 2.32) uU/ml（p < 0.001）：我们的研究没有提供证据证明所调查的 VDR 基因 FokI 多态性与斯洛伐克人群中的 T2DM 有关联。要评估 VDR 基因单核苷酸多态性（SNPs）的影响，还需要进一步的研究，重点是在更大的 T2DM 群体中进行相关的遗传分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Central European journal of public health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： The Journal publishes original articles on disease prevention and health protection, environmental impacts on health, the role of nutrition in health promotion, results of population health studies and critiques of specific health issues including intervention measures such as vaccination and its effectiveness. The review articles are targeted at providing up-to-date information in the sphere of public health. The Journal is geographically targeted at the European region but will accept specialised articles from foreign sources that contribute to public health issues also applicable to the European cultural milieu.