David Murrugarra, Alan Veliz-Cuba, Elena Dimitrova, Claus Kadelka, Matthew Wheeler, Reinhard Laubenbacher
{"title":"Modular Control of Biological Networks","authors":"David Murrugarra, Alan Veliz-Cuba, Elena Dimitrova, Claus Kadelka, Matthew Wheeler, Reinhard Laubenbacher","doi":"arxiv-2401.12477","DOIUrl":null,"url":null,"abstract":"The concept of control is central to understanding and applications of\nbiological network models. Some of their key structural features relate to\ncontrol functions, through gene regulation, signaling, or metabolic mechanisms,\nand computational models need to encode these. Applications of models often\nfocus on model-based control, such as in biomedicine or metabolic engineering.\nThis paper presents an approach to model-based control that exploits two common\nfeatures of biological networks, namely their modular structure and canalizing\nfeatures of their regulatory mechanisms. The paper focuses on intracellular\nregulatory networks, represented by Boolean network models. A main result of\nthis paper is that control strategies can be identified by focusing on one\nmodule at a time. This paper also presents a criterion based on canalizing\nfeatures of the regulatory rules to identify modules that do not contribute to\nnetwork control and can be excluded. For even moderately sized networks,\nfinding global control inputs is computationally very challenging. The modular\napproach presented here leads to a highly efficient approach to solving this\nproblem. This approach is applied to a published Boolean network model of blood\ncancer large granular lymphocyte (T-LGL) leukemia to identify a minimal control\nset that achieves a desired control objective.","PeriodicalId":501325,"journal":{"name":"arXiv - QuanBio - Molecular Networks","volume":"43 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"arXiv - QuanBio - Molecular Networks","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/arxiv-2401.12477","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The concept of control is central to understanding and applications of
biological network models. Some of their key structural features relate to
control functions, through gene regulation, signaling, or metabolic mechanisms,
and computational models need to encode these. Applications of models often
focus on model-based control, such as in biomedicine or metabolic engineering.
This paper presents an approach to model-based control that exploits two common
features of biological networks, namely their modular structure and canalizing
features of their regulatory mechanisms. The paper focuses on intracellular
regulatory networks, represented by Boolean network models. A main result of
this paper is that control strategies can be identified by focusing on one
module at a time. This paper also presents a criterion based on canalizing
features of the regulatory rules to identify modules that do not contribute to
network control and can be excluded. For even moderately sized networks,
finding global control inputs is computationally very challenging. The modular
approach presented here leads to a highly efficient approach to solving this
problem. This approach is applied to a published Boolean network model of blood
cancer large granular lymphocyte (T-LGL) leukemia to identify a minimal control
set that achieves a desired control objective.