Debridement using Piezosurgical Device and Incorporation of Autologous Platelet-Rich Fibrin in Management of Stage III Medication-Related Osteonecrosis of the Jaw — A Case study and Review of Literature

IF 0.4 4区医学 Q4 SURGERY

Indian Journal of Surgery Pub Date : 2024-01-23 DOI:10.1007/s12262-024-04040-x

Aishwarya Chatterjee, Manish Sahni, Suresh Singh, Sandeep Jain, Sandeep Jasuja, Rajgovind Sharma, Sudhir Bhandari

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Abstract

Medication-related osteonecrosis of the jaw (MRONJ) is a condition of persistent exposure of bone or an introral/extraoral fistula through which the bone can be probed for more than 8 weeks in a patient who is under treatment with antiresorptive or antiangiogenic agents (bisphosphonates, denosumab, antiangiogenic agents, tyrosine kinase inhibitors, and monoclonal antibody targeting vascular endothelial growth factors) in the maxillofacial region without any previous history radiation therapy to the jaws or obvious metastatic disease to the jaws. High index of suspicion is required to identify this entity and treat them accordingly. We hereby present a case report where we highlighted the methods to establish the diagnosis of medication-related osteonecrosis of the jaw and its complex management from medical management to surgical management with debridement using piezosurgical device along with the incorporation of autologous platelet concentrate and review the literature of this entity.

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使用压电手术器械进行清创并加入自体血小板富集纤维蛋白治疗 III 期药物相关性颌骨坏死--病例研究与文献综述

药物相关性颌骨坏死（MRONJ）是指在颌面部接受抗骨质吸收或抗血管生成药物（双磷酸盐、地诺苏单抗、抗血管生成药物、酪氨酸激酶抑制剂和针对血管内皮生长因子的单克隆抗体）治疗的患者，骨质持续暴露或出现口内/口外瘘管，可通过瘘管探查骨质，时间超过8周、抗血管生成药物、酪氨酸激酶抑制剂和针对血管内皮生长因子的单克隆抗体）治疗，且无颌骨放射治疗史或颌骨明显转移性疾病史的患者。需要高度怀疑才能识别这种疾病并进行相应的治疗。我们在此提交了一份病例报告，重点介绍了确诊药物相关性颌骨坏死的方法，以及从内科治疗到外科手术治疗的复杂处理过程，包括使用压刀装置进行清创，同时加入自体血小板浓缩物，并回顾了有关该病例的文献。

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来源期刊

Indian Journal of Surgery SURGERY-

CiteScore

0.60

自引率

25.00%

发文量

412

审稿时长

6-12 weeks

期刊介绍： The Indian Journal of Surgery is the official publication of the Association of Surgeons of India that considers for publication articles in all fields of surgery. Issues are published bimonthly in the months of February, April, June, August, October and December. The journal publishes Original article, Point of technique, Review article, Case report, Letter to editor, Teachers and surgeons from the past - A short (up to 500 words) bio sketch of a revered teacher or surgeon whom you hold in esteem and Images in surgery, surgical pathology, and surgical radiology. A trusted resource for peer-reviewed coverage of all types of surgery Provides a forum for surgeons in India and abroad to exchange ideas and advance the art of surgery The official publication of the Association of Surgeons of India 92% of authors who answered a survey reported that they would definitely publish or probably publish in the journal again The Indian Journal of Surgery offers peer-reviewed coverage of all types of surgery. The Journal publishes Original articles, Points of technique, Review articles, Case reports, Letters, Images and brief biographies of influential teachers and surgeons. The Journal spans General Surgery, Pediatric Surgery, Neurosurgery, Plastic Surgery, Cardiothoracic Surgery, Vascular Surgery, Rural Surgery, Orthopedic Surgery, Urology, Surgical Oncology, Radiology, Anaesthesia, Trauma Services, Minimal Access Surgery, Endocrine Surgery, GI Surgery, ENT, Colorectal Surgery, surgical practice and research. The Journal provides a forum for surgeons from India and abroad to exchange ideas, to propagate the advancement of science and the art of surgery and to promote friendship among surgeons in India and abroad. This has been a trusted platform for surgons in communicating up-to-date scientific informeation to the community.