A Novel Methylation-Based Model for Prognostic Prediction in Lung Adenocarcinoma

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-23 DOI:10.2174/0113892029277397231228062412

Manyuan Li, Xufeng Deng, Dong Zhou, Xiaoqing Liu, Jigang Dai, Quanxing Liu

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引用次数: 0

Abstract

Objective:: Specific methylation sites have shown promise in the early diagnosis of lung adenocarcinoma (LUAD). However, their utility in predicting LUAD prognosis remains unclear. This study aimed to construct a reliable methylation-based predictor for accurately predicting the prognosis of LUAD patients. Method:: DNA methylation data and survival data from LUAD patients were obtained from the TCGA and a GEO series. A DNA methylation-based signature was developed using univariate least absolute shrinkage and selection operators and multivariate Cox regression models. Result:: Eight CpG sites were identified and validated as optimal prognostic signatures for the overall survival of LUAD patients. Receiver operating characteristic analysis demonstrated the high predictive ability of the eight-site methylation signature combined with clinical factors for overall survival. Conclusion:: This research successfully identified a novel eight-site methylation signature for predicting the overall survival of LUAD patients through bioinformatic integrated analysis of gene methylation markers used in the early diagnosis of lung cancer.

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基于甲基化的新型肺腺癌预后预测模型

目的：：特定的甲基化位点有望用于肺腺癌（LUAD）的早期诊断。然而，它们在预测肺腺癌预后方面的作用仍不明确。本研究旨在构建一种可靠的基于甲基化的预测因子，以准确预测 LUAD 患者的预后。方法：从 TCGA 和 GEO 系列中获取 LUAD 患者的 DNA 甲基化数据和生存数据。使用单变量最小绝对缩减和选择算子以及多变量考克斯回归模型建立了基于DNA甲基化的特征。结果：：鉴定并验证了八个 CpG 位点是 LUAD 患者总生存期的最佳预后特征。接收者操作特征分析表明，八个位点甲基化特征与临床因素相结合，对总生存期具有很高的预测能力。结论本研究通过对肺癌早期诊断中使用的基因甲基化标记进行生物信息学综合分析，成功鉴定出一种新型的八个位点甲基化特征，用于预测 LUAD 患者的总生存率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.