Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) score as a predictive value of Incidental prostate cancer for patients going for Transurethral resection of the prostate (TURP): A Single Center Study

Ahmed Bendari
{"title":"Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) score as a predictive value of Incidental prostate cancer for patients going for Transurethral resection of the prostate (TURP): A Single Center Study","authors":"Ahmed Bendari","doi":"10.1101/2024.01.23.24301670","DOIUrl":null,"url":null,"abstract":"Aims: Prostate cancer is a significant health concern worldwide, and early detection is crucial for effective treatment. This study aimed to investigate the role of the Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) score in detecting prostate cancer in patients undergoing Transurethral Resection of the Prostate (TURP). Additionally, comprehensive analysis was performed to explore clinical parameters associated with incidentally diagnosed prostate cancer post-TURP. Methods: A total of 131 patients with symptomatic bladder outlet obstruction who underwent TURP were included in the study. The patients were divided into two groups: those with benign prostatic hyperplasia (BPH) and those with invasive prostatic carcinoma. The IPC group consisted of patients with both low-grade and high-grade IPC determined by Gleason score. Demographic data, including age, race, medical history, body mass index, smoking and alcohol status, and family history of prostate cancer, were evaluated. Postoperative measurement of specimen weight and prostate-specific antigen (PSA) levels were also analyzed. Result: Results revealed that approximately 50% of patients had BPH, while the remaining 50% had IPC. Patients with IPC, particularly high-grade IPC, had significantly higher PSA levels and lower resected specimen weight compared to those with BPH. The HALP score, which incorporates hemoglobin, albumin, lymphocyte, and platelet levels, showed promise as a discriminatory tool for distinguishing between BPH and IPC, as well as between high-grade IPC and BPH/low-grade IPC. Logistic regression analysis identified increased PSA levels, decreased HALP score, and smaller specimen weight as independent predictive factors for IPC after TURP. Notably, HALP score was the only significant independent predictive factor associated with high-grade IPC. Conclusion: These findings contribute to the understanding of risk factors and diagnostic tools for incidentally detected prostate cancer in patients with bladder outlet obstruction undergoing TURP. The HALP score, along with PSA levels and specimen weight, can aid in the early detection and management of prostate cancer. Further research is warranted to validate these findings and explore the clinical utility of the HALP score in predicting prostate cancer outcomes.","PeriodicalId":501528,"journal":{"name":"medRxiv - Pathology","volume":"53 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.01.23.24301670","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Aims: Prostate cancer is a significant health concern worldwide, and early detection is crucial for effective treatment. This study aimed to investigate the role of the Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) score in detecting prostate cancer in patients undergoing Transurethral Resection of the Prostate (TURP). Additionally, comprehensive analysis was performed to explore clinical parameters associated with incidentally diagnosed prostate cancer post-TURP. Methods: A total of 131 patients with symptomatic bladder outlet obstruction who underwent TURP were included in the study. The patients were divided into two groups: those with benign prostatic hyperplasia (BPH) and those with invasive prostatic carcinoma. The IPC group consisted of patients with both low-grade and high-grade IPC determined by Gleason score. Demographic data, including age, race, medical history, body mass index, smoking and alcohol status, and family history of prostate cancer, were evaluated. Postoperative measurement of specimen weight and prostate-specific antigen (PSA) levels were also analyzed. Result: Results revealed that approximately 50% of patients had BPH, while the remaining 50% had IPC. Patients with IPC, particularly high-grade IPC, had significantly higher PSA levels and lower resected specimen weight compared to those with BPH. The HALP score, which incorporates hemoglobin, albumin, lymphocyte, and platelet levels, showed promise as a discriminatory tool for distinguishing between BPH and IPC, as well as between high-grade IPC and BPH/low-grade IPC. Logistic regression analysis identified increased PSA levels, decreased HALP score, and smaller specimen weight as independent predictive factors for IPC after TURP. Notably, HALP score was the only significant independent predictive factor associated with high-grade IPC. Conclusion: These findings contribute to the understanding of risk factors and diagnostic tools for incidentally detected prostate cancer in patients with bladder outlet obstruction undergoing TURP. The HALP score, along with PSA levels and specimen weight, can aid in the early detection and management of prostate cancer. Further research is warranted to validate these findings and explore the clinical utility of the HALP score in predicting prostate cancer outcomes.
血红蛋白-白蛋白-淋巴细胞-血小板(HALP)评分作为经尿道前列腺切除术(TURP)患者偶发前列腺癌的预测值:一项单中心研究
目的:前列腺癌是全球关注的重大健康问题,早期发现对有效治疗至关重要。本研究旨在探讨血红蛋白-白蛋白-淋巴细胞-血小板(HALP)评分在经尿道前列腺切除术(TURP)患者中检测前列腺癌的作用。此外,还进行了综合分析,以探讨与经尿道前列腺切除术后偶然诊断出的前列腺癌相关的临床参数。研究方法研究共纳入131名接受TURP手术的症状性膀胱出口梗阻患者。患者分为两组:良性前列腺增生症(BPH)患者和浸润性前列腺癌患者。浸润性前列腺癌组包括根据格里森评分确定的低级别和高级别浸润性前列腺癌患者。对人口统计学数据进行了评估,包括年龄、种族、病史、体重指数、吸烟和酗酒状况以及前列腺癌家族史。此外,还分析了术后标本重量和前列腺特异性抗原(PSA)水平的测量结果。结果显示结果显示,约 50%的患者患有良性前列腺增生症,而其余 50%的患者患有前列腺癌。与良性前列腺增生症患者相比,IPC(尤其是高级别IPC)患者的前列腺特异性抗原(PSA)水平明显更高,切除标本的重量也更轻。HALP 评分结合了血红蛋白、白蛋白、淋巴细胞和血小板水平,是区分良性前列腺增生症和 IPC 以及高级别 IPC 和良性前列腺增生症/低级别 IPC 的鉴别工具。逻辑回归分析发现,PSA水平升高、HALP评分降低和标本重量较小是TURP术后IPC的独立预测因素。值得注意的是,HALP 评分是唯一与高级别 IPC 相关的重要独立预测因素。结论:这些发现有助于了解接受 TURP 术的膀胱出口梗阻患者意外发现前列腺癌的风险因素和诊断工具。HALP 评分以及 PSA 水平和标本重量有助于早期发现和治疗前列腺癌。为了验证这些发现并探索 HALP 评分在预测前列腺癌预后方面的临床实用性,有必要开展进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信