Neutrophils in Physiology and Pathology.

IF 28.4 1区医学 Q1 PATHOLOGY

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2024-01-24 DOI:10.1146/annurev-pathmechdis-051222-015009

Alejandra Aroca-Crevillén, Tommaso Vicanolo, Samuel Ovadia, Andrés Hidalgo

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引用次数: 0

Abstract

Infections, cardiovascular disease, and cancer are major causes of disease and death worldwide. Neutrophils are inescapably associated with each of these health concerns, by either protecting from, instigating, or aggravating their impact on the host. However, each of these disorders has a very different etiology, and understanding how neutrophils contribute to each of them requires understanding the intricacies of this immune cell type, including their immune and nonimmune contributions to physiology and pathology. Here, we review some of these intricacies, from basic concepts in neutrophil biology, such as their production and acquisition of functional diversity, to the variety of mechanisms by which they contribute to preventing or aggravating infections, cardiovascular events, and cancer. We also review poorly explored aspects of how neutrophils promote health by favoring tissue repair and discuss how discoveries about their basic biology inform the development of new therapeutic strategies.

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生理学和病理学中的中性粒细胞

感染、心血管疾病和癌症是全球疾病和死亡的主要原因。中性粒细胞与上述每一种健康问题都有着不可避免的联系，它们或保护宿主免受感染，或诱发感染，或加剧感染对宿主的影响。然而，每种疾病的病因都截然不同，要了解中性粒细胞是如何导致这些疾病的，就必须了解这种免疫细胞类型的复杂性，包括它们对生理和病理的免疫和非免疫贡献。在此，我们回顾了其中一些错综复杂的问题，从中性粒细胞生物学的基本概念，如它们的产生和功能多样性的获得，到它们有助于预防或加重感染、心血管事件和癌症的各种机制。我们还回顾了中性粒细胞如何通过促进组织修复来促进健康这一尚未被充分探索的方面，并讨论了有关中性粒细胞基础生物学的发现如何为开发新的治疗策略提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual Review of Pathology-Mechanisms of Disease 医学-病理学

CiteScore

62.60

自引率

0.00%

发文量

期刊介绍： The Annual Review of Pathology: Mechanisms of Disease is a scholarly journal that has been published since 2006. Its primary focus is to provide a comprehensive overview of recent advancements in our knowledge of the causes and development of significant human diseases. The journal places particular emphasis on exploring the current and evolving concepts of disease pathogenesis, as well as the molecular genetic and morphological changes associated with various diseases. Additionally, the journal addresses the clinical significance of these findings. In order to increase accessibility and promote the broad dissemination of research, the current volume of the journal has transitioned from a gated subscription model to an open access format. This change has been made possible through the Annual Reviews' Subscribe to Open program, which allows all articles published in this volume to be freely accessible to readers. As part of this transition, all articles in the journal are published under a Creative Commons Attribution (CC BY) license, which encourages open sharing and use of the research.