Impact of stalling events on microcirculatory hemodynamics in the aged brain

IF 1.9 4区 医学 Q3 HEMATOLOGY
Mohammad Jamshidi, Thomas Ventimiglia, Patrice Sudres, Cong Zhang, Frédéric Lesage, William Rooney, Daniel Schwartz, Andreas A. Linninger
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Abstract

Objective

The role of cerebral microvasculature in cognitive dysfunction can be investigated by identifying the impact of blood flow on cortical tissue oxygenation. In this paper, the impact of capillary stalls on microcirculatory characteristics such as flow and hematocrit (Ht) in the cortical angioarchitecture is studied.

Methods

Using a deterministic mathematical model to simulate blood flow in a realistic mouse cortex, hemodynamics parameters, including pressure, flow, vessel diameter-adjustable hematocrit, and transit time are calculated as a function of stalling events.

Results

Using a non-linear plasma skimming model, it is observed that Ht increases in the penetrating arteries from the pial vessels as a function of cortical depth. The incidence of stalling on Ht distribution along the blood network vessels shows reduction of RBCs around the tissue near occlusion sites and decreased Ht concentration downstream from the blockage points. Moreover, upstream of the occlusion, there is a noticeable increase of the Ht, leading to larger flow resistance due to higher blood viscosity. We predicted marked changes in transit time behavior due to stalls which match trends observed in mice in vivo.

Conclusions

These changes to blood cell quantity and quality may be implicated in the development of Alzheimer's disease and contribute to the course of the illness.

Abstract Image

停滞事件对老年大脑微循环血流动力学的影响。
目的:通过确定血流量对大脑皮层组织氧合的影响,可以研究大脑微血管在认知功能障碍中的作用。本文研究了毛细血管滞留对大脑皮层血管结构中流量和血细胞比容(Ht)等微循环特征的影响:方法:使用确定性数学模型模拟现实小鼠皮层中的血流,计算血流动力学参数,包括压力、流量、血管直径可调血细胞比容和转运时间与滞留事件的函数关系:结果:利用非线性血浆撇取模型观察到,随着皮层深度的增加,从皮层血管穿入动脉的 Ht 也在增加。停滞对沿血网血管 Ht 分布的影响显示,闭塞点附近组织周围的红细胞减少,而堵塞点下游的 Ht 浓度降低。此外,在闭塞点上游,由于血液粘度较高,Ht 明显增加,导致流动阻力增大。我们预测,由于滞流,血流通过时间会发生明显变化,这与在小鼠体内观察到的趋势一致:血细胞数量和质量的这些变化可能与阿尔茨海默氏症的发展有关,并对疾病的进程起着促进作用。
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来源期刊
Microcirculation
Microcirculation 医学-外周血管病
CiteScore
5.00
自引率
4.20%
发文量
43
审稿时长
6-12 weeks
期刊介绍: The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.
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