Mary Iype, Nisha Melempatt, Jesmy James, Sanjeev V Thomas, Ayyappan Anitha
{"title":"Hypomethylation of Wnt signaling regulator genes in developmental language disorder.","authors":"Mary Iype, Nisha Melempatt, Jesmy James, Sanjeev V Thomas, Ayyappan Anitha","doi":"10.2217/epi-2023-0345","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> Developmental language disorder (DLD) is a neurodevelopmental disorder. Considering the pivotal role of epigenetics in neurodevelopment, we examined any altered DNA methylation between DLD and control subjects. <b>Materials & methods:</b> We looked into genome-wide methylation differences between DLD and control groups. The findings were validated by quantitative PCR (qPCR). <b>Results:</b> In the DLD group, differential methylation of CpG sites was observed in the Wnt signaling regulator genes <i>APCDD1</i>, <i>AMOTL1</i>, <i>LRP5</i>, <i>MARK2</i>, <i>TMEM64</i>, <i>TRABD2B</i>, <i>VEPH1</i> and <i>WNT2B</i>. Hypomethylation of <i>APCDD1</i>, <i>LRP5</i> and <i>WNT2B</i> was confirmed by qPCR. <b>Conclusion:</b> This is the first report associating Wnt signaling with DLD. The findings are relevant in the light of the essential role of Wnt in myelination, and of the altered myelination in DLD.</p>","PeriodicalId":11959,"journal":{"name":"Epigenomics","volume":" ","pages":"137-146"},"PeriodicalIF":3.0000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epigenomics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2217/epi-2023-0345","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/24 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Developmental language disorder (DLD) is a neurodevelopmental disorder. Considering the pivotal role of epigenetics in neurodevelopment, we examined any altered DNA methylation between DLD and control subjects. Materials & methods: We looked into genome-wide methylation differences between DLD and control groups. The findings were validated by quantitative PCR (qPCR). Results: In the DLD group, differential methylation of CpG sites was observed in the Wnt signaling regulator genes APCDD1, AMOTL1, LRP5, MARK2, TMEM64, TRABD2B, VEPH1 and WNT2B. Hypomethylation of APCDD1, LRP5 and WNT2B was confirmed by qPCR. Conclusion: This is the first report associating Wnt signaling with DLD. The findings are relevant in the light of the essential role of Wnt in myelination, and of the altered myelination in DLD.
期刊介绍：
Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community.
Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.
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