Clinical variants of the metabolic syndrome in young people living in the Khanty-Mansiysk autonomous region – Yugra

E. V. Korneeva, M. I. Voevoda
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Abstract

Currently the “rejuvenation” and an increase in the number of components of the metabolic syndrome (MS) determine its clinical significance in the earlier development of diabetes mellitus, cardiovascular diseases and related complications. Aim of the study was to investigate the features of the MS clinic picture in a population of young men and womenliving in the Khanty-Mansiysk autonomous region – Yugra.Material and methods. The study included 863 young people between 18 and 44 years of age, including 344 men and women with MS and 519 people in the comparison group. Studied subgroups are represented by non-indigenous men and women living in urban and rural areas, and indigenous rural residents. The analysis of MS clinical and laboratory parameters was carried out and its clinical variants in ethnic groups were identified.Results and its discussion. According to the results of the survey of young people with metabolic syndrome, it was revealed that the combination of abdominal obesity and two components of MS were most common in young people with MS (in 50.0 % men and in 55.5 % women). The study defined regression models for each MS group and threshold values for waist circumference were set, which changes in lipid and carbohydrate metabolism were predicted.Conclusions. In groups with MS, hypertriglyceridemia was determined as its most common component. The study identified the most frequent association of abdominal obesity with hyper-LDL cholesterol and hypertriglyceridemia in patients with metabolic syndrome, in ethnic groups, this combination is more common in indigenous rural men (53.3 %) and in non-indigenous urban women (54.3 %).
汉特-曼西斯克自治区年轻人代谢综合征的临床变异 - Yugra
目前,代谢综合征(MS)的 "年轻化 "和成分数量的增加决定了其在糖尿病、心血管疾病和相关并发症的早期发展中的临床意义。本研究的目的是调查生活在汉特-曼西民族自治区尤格拉地区的青年男女中代谢综合征的临床特征。研究对象包括 863 名 18 至 44 岁的年轻人,其中包括 344 名多发性硬化症患者和 519 名对比组患者。被研究的亚组包括居住在城市和农村地区的非土著男性和女性,以及农村土著居民。对多发性硬化症的临床和实验室参数进行了分析,并确定了其在各民族群体中的临床变异。根据对患有代谢综合征的年轻人的调查结果,发现在患有 MS 的年轻人中,腹部肥胖和 MS 的两个组成部分结合在一起是最常见的(男性占 50.0%,女性占 55.5%)。研究为每个多发性硬化症群体定义了回归模型,并设定了腰围阈值,据此预测脂质和碳水化合物代谢的变化。在多发性硬化症群体中,高甘油三酯血症是最常见的组成部分。研究发现,在代谢综合征患者中,腹部肥胖与高低密度脂蛋白胆固醇和高甘油三酯血症的关系最为密切,在各族裔群体中,这种组合在农村原住民男性(53.3%)和城市非原住民女性(54.3%)中更为常见。
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