Development of Microneedle Based Blood Extraction Device

IF 2.4 4区工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

Journal of Micromechanics and Microengineering Pub Date : 2024-01-12 DOI:10.1088/1361-6439/ad1e34

Chaofeng Dong, Kang-Hyuk Lee, Jong-Hyun Na, Dong-Hyun Joo, Jin-Ho Choi, W. Park

引用次数: 0

Abstract

Microneedles can extract various analytics from the human body in a minimally invasive manner and provide real-time diagnosis, making microneedle-based point-of-care testing (POCT) devices increasingly popular. In this paper, we propose a press-activated blood extraction system that integrates solid microneedles and 3D-printed blood collection devices for efficient blood extraction. The technology combines a solid microneedle array, a high-speed insertion mechanism, a negative pressure generating structure, and a blood reservoir containing lithium heparin anticoagulant into a compact, self-contained device. The device requires minimal training, as blood can be drawn with a simple finger push of the silicone chamber, yielding a blood volume of approximately 400±50 μl. This device is more convenient and less painful than finger sticks and venipuncture.

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开发基于微针的血液提取装置

微针可以以微创方式从人体中提取各种分析结果，并提供实时诊断，因此基于微针的护理点检测（POCT）设备越来越受欢迎。在本文中，我们提出了一种按压激活的血液提取系统，该系统集成了固体微针和三维打印采血装置，可实现高效的血液提取。该技术将固体微针阵列、高速插入机制、负压产生结构和含有肝素锂抗凝剂的储血器整合到一个紧凑、独立的设备中。该装置只需极少的培训，只需用手指按压硅胶腔即可抽取血液，血容量约为 400±50 μl。这种装置比手指扎针和静脉穿刺更方便，痛苦更小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Micromechanics and Microengineering 工程技术-材料科学：综合

CiteScore

4.50

自引率

4.30%

发文量

136

审稿时长

2.8 months

期刊介绍： Journal of Micromechanics and Microengineering (JMM) primarily covers experimental work, however relevant modelling papers are considered where supported by experimental data. The journal is focussed on all aspects of: -nano- and micro- mechanical systems -nano- and micro- electomechanical systems -nano- and micro- electrical and mechatronic systems -nano- and micro- engineering -nano- and micro- scale science Please note that we do not publish materials papers with no obvious application or link to nano- or micro-engineering. Below are some examples of the topics that are included within the scope of the journal: -MEMS and NEMS: Including sensors, optical MEMS/NEMS, RF MEMS/NEMS, etc. -Fabrication techniques and manufacturing: Including micromachining, etching, lithography, deposition, patterning, self-assembly, 3d printing, inkjet printing. -Packaging and Integration technologies. -Materials, testing, and reliability. -Micro- and nano-fluidics: Including optofluidics, acoustofluidics, droplets, microreactors, organ-on-a-chip. -Lab-on-a-chip and micro- and nano-total analysis systems. -Biomedical systems and devices: Including bio MEMS, biosensors, assays, organ-on-a-chip, drug delivery, cells, biointerfaces. -Energy and power: Including power MEMS/NEMS, energy harvesters, actuators, microbatteries. -Electronics: Including flexible electronics, wearable electronics, interface electronics. -Optical systems. -Robotics.