BIOCHEMICAL MARKERS OF BLOOD SERUM AND ARTICULAR CARTILAGE IN DIFFERENT FORMS OF IDIOPATHIC COXARTHROSIS PROGRESSION

ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS Pub Date : 2024-01-16 DOI:10.15674/0030-59872023443-47

Sadrudin Magomedov, Oleksiy Kalashnikov, Larisa Polishchuk, T. Kuzub, V. Zayets

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Abstract

Deformation due to arthrosis of the hip joint affects 40 % of the total number of patients with osteoarthritis, which is from 7 to 25 % of the adult population. For the activity of the pathological process evaluation we studied biochemical changes in the metabolism of collagen, namely: glycosaminoglycans (GAG), hydroxyproline (HP) fractions, collagenase, hyaluronidase activity, etc. Objective. To determine the biochemical changes in blood serum and articular cartilage depending on the form of progression of idiopathic coxarthrosis. Methods. 23 patients were examined (8 (34.8 %) men, 15 (65.2 %) women, age 45‒75 years and more) with idiopathic arthrosis of the hip joint IV stage (Kellgren–Lawrence). Progression forms of idiopathic coxarthrosis were distinguished: group I — rapid (the period from the initial to the final stage of the disease was 5 years and less), II — moderate (5‒10 years), III — slow (over 10 years). Collagenase activity, HP fractions, total GAG content were determined in patients’ blood serum, and collagen content was determined in the cartilage tissue of the femoral head. Results. Compared with the age reference norm in the blood serum of patients of group I activity collagenase increased to 114 %, in II and III — 122 and 135 %, respectively; the content of the free fraction of GP — up to 111, 169, 128 %, respectively; GAG concentrations — up to 110, 122, and 135 %, respectively; protein-bound HP was reduced to 60% in group II, up to 84 % — in group III. In cartilage tissue, the GAG content decreased in group III to 63 %, II — 55 %, I — 47 %; collagen — 32, 25, 24 % in accordance. Conclusions. The course of idiopathic coxarthrosis is determined by metabolic changes in the components of the organic basis of connective and cartilaginous tissues in blood serum. The most profound changes were found in the synthetic phase of HP metabolism, especially in the group with a rapid course disease. A decrease in the content of organic components of connective tissue (GAG and collagen) was determined

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不同形式的特发性髋关节病进展过程中血清和关节软骨的生化指标

在骨关节炎患者总数中，髋关节变形患者占 40%，占成年人口的 7%至 25%。为了评估病理过程的活性，我们研究了胶原代谢的生化变化，即：糖胺聚糖（GAG）、羟脯氨酸（HP）组分、胶原酶、透明质酸酶活性等。目的根据特发性髋关节病的进展形式，确定血清和关节软骨中的生化变化。方法研究对象为特发性髋关节关节炎 IV 期（Kellgren-Lawrence）患者 23 例（男性 8 例（34.8%），女性 15 例（65.2%），年龄 45-75 岁及以上）。特发性髋关节病的进展形式分为：I 组--快速（从疾病初期到最后阶段的时间为 5 年或更短），II 组--中度（5-10 年），III 组--缓慢（10 年以上）。对患者血清中的胶原酶活性、HP组分、GAG总含量进行测定，并对股骨头软骨组织中的胶原含量进行测定。结果显示与年龄参照标准相比，第一组患者血清中的胶原酶活性增加了114%，第二组和第三组分别增加了122%和135%；GP游离部分的含量分别增加了111%、169%和128%；GAG浓度分别增加了110%、122%和135%；蛋白结合的HP在第二组中减少了60%，在第三组中减少了84%。在软骨组织中，第三组的 GAG 含量下降至 63%，第二组为 55%，第一组为 47%；胶原蛋白含量分别为 32%、25% 和 24%。结论特发性髋关节病的病程取决于血清中结缔组织和软骨组织有机基础成分的代谢变化。在HP代谢的合成阶段发现了最深刻的变化，尤其是在病程较快的组别中。结缔组织有机成分（GAG 和胶原蛋白）的含量减少了

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ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS

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