Cerebral Microvascular Perfusion Assessed in Elderly Adults by Spin-Echo Dynamic Susceptibility Contrast MRI at 7 Tesla.

IF 2.2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Tomography Pub Date : 2024-01-18 DOI:10.3390/tomography10010014

Elles P Elschot, Walter H Backes, Marieke van den Kerkhof, Alida A Postma, Abraham A Kroon, Jacobus F A Jansen

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引用次数: 0

Abstract

Perfusion measures of the total vasculature are commonly derived with gradient-echo (GE) dynamic susceptibility contrast (DSC) MR images, which are acquired during the early passes of a contrast agent. Alternatively, spin-echo (SE) DSC can be used to achieve specific sensitivity to the capillary signal. For an improved contrast-to-noise ratio, ultra-high-field MRI makes this technique more appealing to study cerebral microvascular physiology. Therefore, this study assessed the applicability of SE-DSC MRI at 7 T. Forty-one elderly adults underwent 7 T MRI using a multi-slice SE-EPI DSC sequence. The cerebral blood volume (CBV) and cerebral blood flow (CBF) were determined in the cortical grey matter (CGM) and white matter (WM) and compared to values from the literature. The relation of CBV and CBF with age and sex was investigated. Higher CBV and CBF values were found in CGM compared to WM, whereby the CGM-to-WM ratios depended on the amount of largest vessels excluded from the analysis. CBF was negatively associated with age in the CGM, while no significant association was found with CBV. Both CBV and CBF were higher in women compared to men in both CGM and WM. The current study verifies the possibility of quantifying cerebral microvascular perfusion with SE-DSC MRI at 7 T.

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通过 7 特斯拉自旋回波动态感知对比 MRI 评估老年人的脑微血管灌注情况

整个血管的灌注测量通常是通过梯度回波（GE）动态易感对比（DSC）磁共振图像得出的，这些图像是在造影剂通过的早期采集的。另外，自旋回波（SE）DSC 也可用于实现对毛细血管信号的特定敏感性。为了提高对比度与噪声比，超高场强磁共振成像使这项技术在研究脑微血管生理学方面更具吸引力。因此，本研究评估了 SE-DSC 核磁共振成像在 7 T 的适用性。41 位老年人使用多切片 SE-EPI DSC 序列接受了 7 T 核磁共振成像。测定了大脑皮层灰质（CGM）和白质（WM）的脑血容量（CBV）和脑血流量（CBF），并与文献中的数值进行了比较。研究还调查了 CBV 和 CBF 与年龄和性别的关系。与 WM 相比，CGM 中的 CBV 和 CBF 值更高，而 CGM 与 WM 的比率取决于分析中排除的最大血管的数量。在 CGM 中，CBF 与年龄呈负相关，而与 CBV 则无明显关联。在 CGM 和 WM 中，女性的 CBV 和 CBF 均高于男性。本研究验证了在 7 T 下用 SE-DSC MRI 定量脑微血管灌注的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tomography Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

2.70

自引率

10.50%

发文量

222

期刊介绍： TomographyTM publishes basic (technical and pre-clinical) and clinical scientific articles which involve the advancement of imaging technologies. Tomography encompasses studies that use single or multiple imaging modalities including for example CT, US, PET, SPECT, MR and hyperpolarization technologies, as well as optical modalities (i.e. bioluminescence, photoacoustic, endomicroscopy, fiber optic imaging and optical computed tomography) in basic sciences, engineering, preclinical and clinical medicine. Tomography also welcomes studies involving exploration and refinement of contrast mechanisms and image-derived metrics within and across modalities toward the development of novel imaging probes for image-based feedback and intervention. The use of imaging in biology and medicine provides unparalleled opportunities to noninvasively interrogate tissues to obtain real-time dynamic and quantitative information required for diagnosis and response to interventions and to follow evolving pathological conditions. As multi-modal studies and the complexities of imaging technologies themselves are ever increasing to provide advanced information to scientists and clinicians. Tomography provides a unique publication venue allowing investigators the opportunity to more precisely communicate integrated findings related to the diverse and heterogeneous features associated with underlying anatomical, physiological, functional, metabolic and molecular genetic activities of normal and diseased tissue. Thus Tomography publishes peer-reviewed articles which involve the broad use of imaging of any tissue and disease type including both preclinical and clinical investigations. In addition, hardware/software along with chemical and molecular probe advances are welcome as they are deemed to significantly contribute towards the long-term goal of improving the overall impact of imaging on scientific and clinical discovery.