Machine-learning-based mapping of blood oxygen saturation from dual-wavelength optoacoustic measurements

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-19 DOI:10.1088/1612-202x/ad1aa4

D A Kurakina, M Yu Kirillin, A V Khilov, V V Perekatova

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Abstract

We developed a novel machine-learning-based algorithm based on a gradient boosting regressor for three-dimensional pixel-by-pixel mapping of blood oxygen saturation based on dual-wavelength optoacoustic data. Algorithm training was performed on in silico data produced from Monte-Carlo-generated absorbed light energy distributions in tissue-like vascularized media for probing wavelengths of 532 and 1064 nm and the empirical instrumental function of the optoacoustic imaging setup with further validation of the independent in silico data. In vivo optoacoustic data for rabbit-ear vasculature was employed as a testing dataset. The developed algorithm allowed in vivo blood oxygen saturation mapping and showed clear differences in blood oxygen saturation values in veins at 15 °C and 43 °C due to functional arteriovenous anastomoses. These results indicated that dual-wavelength optoacoustic imaging could serve as a cost-effective alternative to complicated multiwavelength quantitative optoacoustic imaging.

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基于机器学习的双波长光声测量血氧饱和度绘图

我们开发了一种基于梯度提升回归器的新型机器学习算法，可根据双波长光声数据逐像素绘制三维血氧饱和度图。该算法的训练是根据蒙特卡罗生成的类组织血管介质吸收光能量分布（探测波长为 532 和 1064 nm）以及光声成像装置的经验仪器功能生成的硅学数据进行的，并对独立的硅学数据进行了进一步验证。兔耳血管的活体光声数据被用作测试数据集。所开发的算法可绘制活体血氧饱和度图，并显示由于动静脉功能性吻合，静脉在 15 ℃ 和 43 ℃ 时的血氧饱和度值存在明显差异。这些结果表明，双波长光声成像可作为复杂的多波长定量光声成像的一种经济有效的替代方法。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.