Antioxidant and Cardioprotective Property of Polyphenols from Natural Sources on Protein Denaturation and Vasorelaxation in Chick Embryo Model: A Replacing Study for Animal Model Testing

IF 2.8 3区化学 Q2 CHEMISTRY, APPLIED

Topics in Catalysis Pub Date : 2024-01-17 DOI:10.1007/s11244-023-01896-3

Azhagu Saravana Babu Packirisamy, Vajiha Aafrin Basheer, Sai Nandhini Ravi, Muthumareeswaran Muthuramamoorthy, Salim Manoharadas, Chandra Mohan Chandrasekar, Sukumar Muthusamy

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Abstract

The aim of the study is focussed on investigating the dietary polyphenols and antioxidant potential of Nardostachys jatamansi rhizomes extract (NJRE) and peel extracts of Musa acuminata (red banana) and correlates these findings with specific therapeutic properties. The polyphenolic and phytochemical content of Nardostachys jatamansi rhizomes and peel of Musa acuminata (red banana) extract was evaluated by radical scavenging methods with spectrophotometric and the vasorelaxation study was done on chick embryo model with anti-cholesterol and anti-inflammatory properties. The nutraceutical properties were carried out by estimating the maximum levels of total phenolic (142.1 mg GE/g) for NJRE and (138.3 ± 0.5 mg GE/g) for banana peel extracts. The polyphenols effectively involved in the promotion of anti-inflammatory (79.6%), anti-cholesterol activity (95.35 ± 0.5) with the maximum pancreatic cholesterol esterase inhibition of 98.21% and also enhanced the vasorelaxation by stimulating the smooth muscle in chick embryo (Gallus gallus domesticus). A strong correlation between the polyphenols and therapeutic characteristics of NJRE and banana peel was observed and the polyphenols highlighted a synergism of vasorelaxation. The results from our study will provide a scientific basis for high through put utilization of NJRE and banana peel for the development of nutraceuticals for disease management.

Graphical Abstract

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天然来源多酚对雏鸡胚胎模型蛋白质变性和血管舒张的抗氧化和心脏保护特性：替代动物模型测试的研究

这项研究的目的是重点调查桔梗根茎提取物（NJRE）和红香蕉（Musa acuminata）果皮提取物的膳食多酚和抗氧化潜力，并将这些发现与特定的治疗特性联系起来。用分光光度法清除自由基的方法评估了桔梗根茎提取物和红香蕉（Musa acuminata）果皮提取物的多酚和植物化学成分含量，并在小鸡胚胎模型上进行了具有抗胆固醇和抗炎特性的血管舒张研究。通过估算总酚的最高水平（142.1 毫克 GE/克）（南极果提取物）和（138.3 ± 0.5 毫克 GE/克）（香蕉皮提取物），确定了其营养保健特性。这些多酚有效地促进了抗炎（79.6%）和抗胆固醇活性（95.35 ± 0.5），对胰腺胆固醇酯酶的最大抑制率为 98.21%，还通过刺激雏鸡胚胎（Gallus gallus domesticus）平滑肌增强了血管舒张功能。据观察，南极红景天和香蕉皮的多酚类物质与治疗特性之间存在很强的相关性，多酚类物质突出了血管舒张的协同作用。我们的研究结果将为大量利用南极红景天和香蕉皮开发用于疾病治疗的营养保健品提供科学依据。

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来源期刊

Topics in Catalysis 化学-物理化学

CiteScore

5.70

自引率

5.60%

发文量

197

审稿时长

2 months

期刊介绍： Topics in Catalysis publishes topical collections in all fields of catalysis which are composed only of invited articles from leading authors. The journal documents today’s emerging and critical trends in all branches of catalysis. Each themed issue is organized by renowned Guest Editors in collaboration with the Editors-in-Chief. Proposals for new topics are welcome and should be submitted directly to the Editors-in-Chief. The publication of individual uninvited original research articles can be sent to our sister journal Catalysis Letters. This journal aims for rapid publication of high-impact original research articles in all fields of both applied and theoretical catalysis, including heterogeneous, homogeneous and biocatalysis.