Herbal-based compounds: A review on treatments of cryptosporidiosis

IF 4.1 2区医学 Q1 PARASITOLOGY

International Journal for Parasitology: Drugs and Drug Resistance Pub Date : 2024-01-14 DOI:10.1016/j.ijpddr.2024.100521

Fatemeh Namazi, Seyed Mostafa Razavi

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Abstract

Cryptosporidium, a monoxenous apicomplexan coccidia, is a prevalent diarrhetic and an opportunistic agent, mainly in immunocompromised individuals. As there are few chemotherapeutic compounds that have limited efficacy, we need to identify new compounds or specific parasite targets for designing more potent drugs to treat cryptosporidiosis. Herbal products with low toxicity, environmental compatibility, wide therapeutic potential, and abundant resources can be considered alternatives for treatment. The current review tried to summarize the studies on plants or herbal bioactive constituents with anti-cryptosporidial activities. Based on constituents, plants act via different mechanisms, and further investigations are needed to clarify the exact mechanisms by which they act on the developmental stages of the parasite or host-parasite relationships.

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以草药为基础的化合物：隐孢子虫病治疗综述

隐孢子虫是一种单性无丝分裂球虫，是一种常见的腹泻病原体和机会性病原体，主要发生在免疫力低下的人群中。由于目前的化疗化合物很少，而且疗效有限，我们需要找到新的化合物或特定的寄生虫靶点，以设计出更有效的药物来治疗隐孢子虫病。草药产品具有毒性低、环境相容性好、治疗潜力大、资源丰富等特点，可作为治疗隐孢子虫病的替代品。本综述试图总结有关具有抗隐孢子虫活性的植物或草药生物活性成分的研究。根据成分的不同，植物通过不同的机制发挥作用，需要进一步研究以明确它们对寄生虫发育阶段或宿主-寄生虫关系发挥作用的确切机制。

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来源期刊

International Journal for Parasitology: Drugs and Drug Resistance PARASITOLOGY-PHARMACOLOGY & PHARMACY

CiteScore

7.90

自引率

7.50%

发文量

审稿时长

48 days

期刊介绍： The International Journal for Parasitology – Drugs and Drug Resistance is one of a series of specialist, open access journals launched by the International Journal for Parasitology. It publishes the results of original research in the area of anti-parasite drug identification, development and evaluation, and parasite drug resistance. The journal also covers research into natural products as anti-parasitic agents, and bioactive parasite products. Studies can be aimed at unicellular or multicellular parasites of human or veterinary importance.