Association of metformin use with abdominal aortic aneurysm: A systematic review and meta-analysis.

IF 0.7 Q3 Medicine

ASIAN CARDIOVASCULAR & THORACIC ANNALS Pub Date : 2024-03-01 Epub Date: 2024-01-18 DOI:10.1177/02184923231225794

Raditya Dewangga, Kevin Winston, Lazuardi Gayu Ilhami, Suci Indriani, Taofan Siddiq, Suko Adiarto

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Abstract

Background: Abdominal aortic aneurysm (AAA) is a cardiovascular disease characterized by a high mortality rate when ruptured. Some studies suggest a potential inverse correlation between AAA and diabetes patients, especially those undergoing metformin treatment. However, this relationship remains unclear. This paper offers a systematic review and meta-analysis with the objective of clarifying the influence of metformin on AAA.

Methods: A search for relevant articles was performed across multiple databases including PubMed, ScienceDirect, Cochrane and Scopus. The focus was on studies that examined the comparative effects of metformin and non-metformin treatments on AAA patients. Data from appropriate studies were consolidated to estimate the effects. Our study encompassed 11 articles, comprising 13 cohorts that compared metformin (n = 32,250) with a control group (n = 116,339).

Results: The random effects meta-analysis revealed that metformin was associated with a slower growth rate (weighted mean difference (WMD) -0.86 mm; 95% CI: -1.21 to -0.52; p < 0.01; I²: 81.4%) and fewer AAA-related events (OR: 0.54; 95% CI: 0.34 to 0.86; p = 0.01; I²: 60.9%). The findings suggest that metformin may be linked to a reduced risk of aortic aneurysm. A meta-regression analysis indicated that the association between metformin and AAA growth was significantly influenced by male gender (p = 0.027), but not by age (p = 0.801), hypertension (p = 0.256), DM (p = 0.689), smoking history (p = 0.786), use of lipid-lowering agents (p = 0.715), or baseline diameter (p = 0.291).

Conclusion: These results hint at a potential role for metformin in limiting annual AAA growth, AAA-related events, and the risk of AAA.

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使用二甲双胍与腹主动脉瘤的关系：系统回顾和荟萃分析。

背景：腹主动脉瘤（AAA）是一种心血管疾病，一旦破裂死亡率很高。一些研究表明，腹主动脉瘤与糖尿病患者，尤其是接受二甲双胍治疗的糖尿病患者之间可能存在反向相关性。然而，这种关系仍不明确。本文进行了系统回顾和荟萃分析，旨在阐明二甲双胍对 AAA 的影响：方法：在多个数据库（包括 PubMed、ScienceDirect、Cochrane 和 Scopus）中搜索相关文章。重点研究了二甲双胍和非二甲双胍治疗对 AAA 患者的比较效果。我们整合了相关研究的数据，以估算其效果。我们的研究包括 11 篇文章，其中 13 个队列对二甲双胍（32,250 人）和对照组（116,339 人）进行了比较：随机效应荟萃分析显示，二甲双胍与生长速度减慢（加权平均差 (WMD) -0.86 mm；95% CI：-1.21 至 -0.52；P 2：81.4%）和 AAA 相关事件减少（OR：0.54；95% CI：0.34 至 0.86；P = 0.01；I2：60.9%）有关。研究结果表明，二甲双胍可能与主动脉瘤风险的降低有关。元回归分析表明，二甲双胍与 AAA 生长之间的关系受男性性别（p = 0.027）的显著影响，但不受年龄（p = 0.801）、高血压（p = 0.256）、糖尿病（p = 0.689）、吸烟史（p = 0.786）、降脂药物的使用（p = 0.715）或基线直径（p = 0.291）的影响：这些结果提示了二甲双胍在限制 AAA 年增长率、AAA 相关事件和 AAA 风险方面的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ASIAN CARDIOVASCULAR & THORACIC ANNALS Multiple-

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The Asian Cardiovascular and Thoracic Annals is an international peer-reviewed journal pertaining to cardiovascular and thoracic medicine. Besides original clinical manuscripts, we welcome research reports, product reviews, reports of new techniques, and findings of special significance to Asia and the Pacific Rim. Case studies that have significant novel original observations, are instructive, include adequate methodological details and provide conclusions. Workshop proceedings, meetings and book reviews, letters to the editor, and meeting announcements are encouraged along with relevant articles from authors.