He Hu , Weichao Xu , Yan Li , Zhicheng Wang , Siyue Wang , Yansheng Liu , Minan Bai , Yingying Lou , Qian Yang
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引用次数: 0
Abstract
Endoplasmic reticulum (ER) stress plays a key role in the pathogenesis of several organ damages. Studies show that excessive ER stress (ERS) can destroy cellular homeostasis, causing cell damage and physiological dysfunction in various organs. In recent years, Sirtuin1 (SIRT1) has become a research hotspot on ERS. Increasing evidence suggests that SIRT1 plays a positive role in various ERS-induced organ damage via multiple mechanisms, including inhibiting cellular apoptosis and promoting autophagy. SIRT1 can also alleviate liver, heart, lung, kidney, and intestinal damage by inhibiting ERS. We discuss the possible mechanism of SIRT1, explore potential therapeutic targets of diseases, and provide a theoretical basis for treating ERS-related diseases.
内质网（ER）应激在多种器官损伤的发病机制中起着关键作用。研究表明，过度的ER应激（ERS）会破坏细胞的稳态，造成细胞损伤和多种器官的生理功能障碍。近年来，Sirtuin1（SIRT1）已成为ERS的研究热点。越来越多的证据表明，SIRT1 通过多种机制在各种 ERS 引起的器官损伤中发挥着积极作用，包括抑制细胞凋亡和促进自噬。SIRT1 还能通过抑制 ERS 减轻肝、心、肺、肾和肠道损伤。我们讨论了 SIRT1 的可能机制，探索了疾病的潜在治疗靶点，为治疗 ERS 相关疾病提供了理论依据。
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