Effect of breast milk intake volume on early behavioral neurodevelopment of extremely preterm infants.

IF 2.9 2区医学 Q1 OBSTETRICS & GYNECOLOGY

International Breastfeeding Journal Pub Date : 2024-01-17 DOI:10.1186/s13006-024-00612-5

Ying Gao, Xiaoyu Lu, Mengqing Pan, Chuntian Liu, Yuxiao Min, Xiaochun Chen

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Abstract

Background: This study aimed to explore the effects of breast milk feeding volume on the early behavioral neurodevelopment of extremely preterm infants (gestational age < 28 weeks).

Methods: The study was conducted from 1 January 2021 to 31 March 2023. A total of 187 preterm infants from a neonatal intensive care unit (NICU) in a Grade III Class A hospital in Zhejiang, China, were divided based on the proportion of breast milk in their total enteral nutrition: high proportion (≥ 80%, including exclusive breast milk feeding), medium proportion (20% ~ < 80%), and low proportion (< 20%). The study investigated motor performance and behavioral neurodevelopment at 37 weeks of corrected gestational age, as well as the total incidence of intracranial hemorrhage within the first four weeks postpartum.

Results: The low breast milk feeding group had significantly lower scores in infant motor performance (31.34 ± 5.85) and elicited item scores (19.89 ± 5.55) compared to the medium and high groups (33.52 ± 4.33, 22.13 ± 4.22; and 35.86 ± 5.27, 23.91 ± 4.98), p < 0.05, respectively. Despite no significant difference in behavioral ability, the low proportion group exhibited lower passive muscle tension and primitive reflex scores than the medium and high proportion groups. The high proportion group showed higher active muscle tension scores. Ultrasound results revealed varying incidences of intracranial hemorrhage: 72.9% in low, 52.5% in medium, and 19.6% in the high proportion groups.

Conclusions: Medium to high levels of breast milk feeding contribute positively to motor and behavioral neurological development in extremely preterm infants and decrease the likelihood of ventricular hemorrhage. However, it does not have a significant effect on the development of behavioral abilities. Due to the limited sample size, the next step will be to expand the sample size and further investigate the extent of the impact on various aspects of the nervous system.

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母乳摄入量对极早产儿早期行为神经发育的影响

研究背景本研究旨在探讨母乳喂养量对极早产儿（胎龄方法）早期行为神经发育的影响：研究时间为 2021 年 1 月 1 日至 2023 年 3 月 31 日。根据母乳占总肠内营养的比例，将浙江某三级甲等医院新生儿重症监护室（NICU）的 187 名早产儿分为：高比例组（≥80%，包括纯母乳喂养）、中等比例组（20% ~ < 80%）和低比例组（结果：高比例组母乳喂养量明显低于中等比例组（20% ~ < 80%））：低母乳喂养组的婴儿运动表现得分（31.34 ± 5.85）和诱发项目得分（19.89 ± 5.55）明显低于中母乳喂养组和高母乳喂养组（33.52 ± 4.33，22.13 ± 4.22；35.86 ± 5.27，23.91 ± 4.98），P 结论：低母乳喂养组的婴儿运动表现得分（31.34 ± 5.85）和诱发项目得分（19.89 ± 5.55）明显低于中母乳喂养组和高母乳喂养组：中高水平的母乳喂养对极早产儿的运动和行为神经发育有积极作用，并能降低脑室出血的可能性。但是，母乳喂养对行为能力的发展没有显著影响。由于样本量有限，下一步将扩大样本量，进一步研究母乳对神经系统各方面的影响程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Breastfeeding Journal Medicine-Obstetrics and Gynecology

CiteScore

6.30

自引率

11.40%

发文量

审稿时长

32 weeks

期刊介绍： Breastfeeding is recognized as an important public health issue with enormous social and economic implications. Infants who do not receive breast milk are likely to experience poorer health outcomes than breastfed infants; mothers who do not breastfeed increase their own health risks. Publications on the topic of breastfeeding are wide ranging. Articles about breastfeeding are currently published journals focused on nursing, midwifery, paediatric, obstetric, family medicine, public health, immunology, physiology, sociology and many other topics. In addition, electronic publishing allows fast publication time for authors and Open Access ensures the journal is easily accessible to readers.