Correlation between the Systemic Immunoinflammatory Index and Platelet–Lymphocyte Ratio in Patients with Adenomyosis

IF 4.4 3区 医学 Q2 CELL BIOLOGY
Yan Dong, YaHui Chen, YaNan Wang, Lin Wang, Yan Zhou, Mei Xue, Lin Sun
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引用次数: 0

Abstract

Background. The chronic inflammatory immune response is a significant factor in the pathogenesis of benign gynecological diseases. The systemic immunoinflammatory index (SII) and the platelet-to-lymphocyte ratio (PLR) are commonly available biomarkers of inflammation. However, evidence of the relationship between SII and PLR in patients with adenomyosis is limited. This study aimed to investigate the relationship between SII and PLR in patients with adenomyosis. Methods. This cross-sectional study included 483 patients with adenomyosis who were first diagnosed at our institution between January 2019 and December 2021. Basic patient clinical information and inflammatory factors were collected for univariate analysis, smoothed curve fitting, and multivariate segmented linear regression. Results. The results of the univariate analysis showed a significant positive correlation between PLR levels and SII (). In addition, a nonlinear relationship between PLR and SII was tested using a smoothed curve fit after adjusting for potential confounders. Multiple segmented linear regression models showed a significant relationship between SII and PLR in both SII < 1,326.47 (β 0.14, 95% CI: 0.12, 0.16; ) and >1,326.47 (β 0.02, 95% CI: −0.01, 0.05; P = 0.2461). Conclusions. In conclusion, this study showed a nonlinear relationship between SII and PLR in patients with uterine adenomyosis. An increase in serum PLR levels correlates with an increase in SII before SII levels reach an inflection point.
子宫腺肌症患者的全身免疫炎症指数与血小板-淋巴细胞比率之间的相关性
背景。慢性炎症免疫反应是良性妇科疾病发病机制中的一个重要因素。全身免疫炎症指数(SII)和血小板淋巴细胞比值(PLR)是常用的炎症生物标志物。然而,有关子宫腺肌症患者 SII 和 PLR 之间关系的证据却很有限。本研究旨在调查腺肌症患者的 SII 与 PLR 之间的关系。研究方法这项横断面研究纳入了2019年1月至2021年12月期间在我院首次确诊的483名腺肌症患者。收集患者的基本临床信息和炎症因素,进行单变量分析、平滑曲线拟合和多变量分段线性回归。结果单变量分析结果显示,PLR 水平与 SII()呈显著正相关。此外,在调整了潜在的混杂因素后,使用平滑曲线拟合检验了 PLR 与 SII 之间的非线性关系。多元分段线性回归模型显示,在 SII < 1,326.47 (β 0.14, 95% CI: 0.12, 0.16;) 和 >1,326.47 (β 0.02, 95% CI: -0.01, 0.05; P = 0.2461) 中,SII 与 PLR 之间均存在显著关系。结论总之,本研究显示子宫腺肌症患者的 SII 与 PLR 之间存在非线性关系。在 SII 水平达到拐点之前,血清 PLR 水平的增加与 SII 的增加相关。
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来源期刊
Mediators of Inflammation
Mediators of Inflammation 医学-免疫学
CiteScore
8.70
自引率
0.00%
发文量
202
审稿时长
4 months
期刊介绍: Mediators of Inflammation is a peer-reviewed, Open Access journal that publishes original research and review articles on all types of inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules.
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