Effects of Ziprasidone or Haloperidol on Theory of Mind in Patients With Schizophrenia: A 16-week Pilot Trial.

IF 1.3 4区 医学 Q3 PSYCHIATRY
Jie Zhong, Yuan Jia, Hong Zhu, Dan Wang, Hongxiao Jia
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引用次数: 0

Abstract

Objectives: Schizophrenia is associated with impairment in theory of mind (ToM), which is defined as the ability to make judgments about mental states and is related to medial prefrontal cortical activity. Ziprasidone, but not haloperidol, is known to have a protective effect in the medial prefrontal cortex. Thus, we hypothesized that these 2 drugs would have different efficacy in improving ToM task performance in patients with schizophrenia.

Methods: Patients with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) diagnosis of schizophrenia matched for sex, duration of illness, and education were randomized to receive ziprasidone (n=30) or haloperidol (n=30). All patients were assessed using the Positive and Negative Syndrome Scale and the Personal and Social Functioning Scale. ToM was assessed using a first-order false belief task, a second-order false belief task, the faux-pas task, and the Reading the Mind in the Eyes Task, in order of developmental complexity and difficulty. The primary outcome was change in ToM performance from baseline to 16 weeks of treatment.

Results: For the first-order false belief task, there were no significant differences between the groups (P>0.05). For the second-order false belief task, the interaction effect was significant (P<0.05), and the simple effect of time showed a significant difference only in the ziprasidone group (P<0.001). For the faux-pas task, the interaction effect was not significant (P>0.05). For the Reading the Mind in the Eyes Task, the interaction effect was significant (P<0.05), and the simple effect of time showed a significant difference only in the ziprasidone group (P<0.001). The Positive and Negative Syndrome Scale results were similar between the groups. The ziprasidone group performed better than the haloperidol group on the Personal and Social Functioning Scale. There were no major safety concerns or adverse events.

Conclusions: The findings of this study suggest that ziprasidone could improve ToM and might be superior to haloperidol for improving complex ToM as well as personal and social functioning in patients with schizophrenia.

Trial registration chinese clinical trial register: ChiCTR2200060542.

齐拉西酮或氟哌啶醇对精神分裂症患者思维理论的影响:为期16周的试点试验。
研究目的精神分裂症与心智理论(ToM)受损有关,心智理论被定义为对精神状态做出判断的能力,与内侧前额叶皮层的活动有关。众所周知,齐拉西酮(Ziprasidone)而非氟哌啶醇(haloperidol)对内侧前额叶皮质具有保护作用。因此,我们假设这两种药物在改善精神分裂症患者ToM任务表现方面具有不同的疗效:方法:对性别、病程和教育程度相匹配的精神分裂症诊断与统计手册第四版(DSM-IV)诊断患者进行随机分组,接受齐拉西酮(30 人)或氟哌啶醇(30 人)治疗。所有患者均使用 "积极与消极综合征量表 "和 "个人与社会功能量表 "进行评估。按照发展的复杂程度和难度,依次使用一阶错误信念任务、二阶错误信念任务、伪装任务和 "读心术 "任务对 ToM 进行评估。主要结果是从基线到治疗 16 周期间 ToM 表现的变化:结果:在一阶假想任务中,两组之间没有显著差异(P>0.05)。在二阶错误信念任务中,交互作用效果显著(P0.05)。在 "读心术 "任务中,交互作用效应显著(P0.05):本研究结果表明,齐拉西酮可以改善精神分裂症患者的ToM,在改善复杂ToM以及个人和社会功能方面可能优于氟哌啶醇:ChiCTR2200060542。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.30
自引率
10.50%
发文量
159
审稿时长
>12 weeks
期刊介绍: Journal of Psychiatric Practice® seizes the day with its emphasis on the three Rs — readability, reliability, and relevance. Featuring an eye-catching style, the journal combines clinically applicable reviews, case studies, and articles on treatment advances with practical and informative tips for treating patients. Mental health professionals will want access to this review journal — for sharpening their clinical skills, discovering the best in treatment, and navigating this rapidly changing field. Journal of Psychiatric Practice combines clinically applicable reviews, case studies, and articles on treatment advances with informative "how to" tips for surviving in a managed care environment.
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