Intracranial meningioma: an unusual silent killer—about two cases report and a literature review

IF 1.3 Q3 MEDICINE, LEGAL
Mohamed Amine Mesrati, Oumeima Brahim, Marwa Boussaid, Rakia Soiniya, Yosra Mahjoub, Nouha Ben Abdeljelil, Atef Ben Ncir, Abdelfattah Zakhama, Abir Aissaoui
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引用次数: 0

Abstract

Meningiomas are common benign intracranial tumors, accounting for 1/3 of all primary intracranial neoplasms, and hence, are not considered the chief cause of death when encountered incidentally during autopsy. These tumors are usually slow-growing, and the clinical course may be asymptomatic to the point of acute complications. Sudden unexpected deaths due to meningiomas are exceptional and rarely reported in the literature. In the present report, we describe two autopsy cases of sudden unexpected death due to meningiomas and we discuss the mechanism of death. Two apparently healthy men were discovered dead in their home. A judicial autopsy was ordered. At dissection, a pedunculated firm mass, attached to the dura was found in both cases. Tumors were located in the anterior and middle fossa. The remaining organs were congestive without any abnormality. A microscopic examination confirmed the diagnosis of meningiomas. Postmortem toxicology analysis was negative. Forensic pathologists concluded to sudden unexpected death due to intracranial meningioma. These cases illustrate the possibility of meningioma remaining silent till acute complication and fatal outcome. Therefore, clinicians must bear in mind the possibility, albeit extremely rare, of sudden unexpected death in cases of undiagnosed intracranial meningiomas, as documented in the present report. Thus, we emphasize the value of promptly and thoroughly investigating even seemingly minor neurological symptoms, such as headaches or acute epileptic seizures, in adults. We also stress the importance of the early detection and appropriate management of brain tumors in fatal outcome prevention, and we highlight the role of the post-mortem examination to detect such a fatal complication.
颅内脑膜瘤:不寻常的沉默杀手--约两例报告和文献综述
脑膜瘤是常见的颅内良性肿瘤,占所有原发性颅内肿瘤的 1/3,因此,在尸检中偶然发现的脑膜瘤并不被认为是死亡的主要原因。这些肿瘤通常生长缓慢,临床过程中可能没有症状,甚至会出现急性并发症。脑膜瘤导致的意外猝死是罕见的,在文献中也鲜有报道。在本报告中,我们描述了两例因脑膜瘤意外猝死的尸检病例,并讨论了死亡机制。两名看似健康的男子被发现死于家中。他们被要求进行司法解剖。解剖时,两个病例都发现了与硬脑膜相连的有蒂坚实肿块。肿瘤位于前窝和中窝。其余器官充血,未见异常。显微镜检查证实了脑膜瘤的诊断。死后毒理分析呈阴性。法医病理学家的结论是颅内脑膜瘤导致猝死。这些病例说明了脑膜瘤在急性并发症和致命结果发生之前保持沉默的可能性。因此,临床医生必须牢记,在未确诊的颅内脑膜瘤病例中存在意外猝死的可能性,尽管这种情况极为罕见,本报告中就有记录。因此,我们强调,即使是看似轻微的神经系统症状,如头痛或急性癫痫发作,也要及时、彻底地进行检查。我们还强调了早期发现和妥善处理脑肿瘤对预防致命后果的重要性,并着重指出了尸检在发现这种致命并发症方面的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.00
自引率
0.00%
发文量
51
审稿时长
17 weeks
期刊介绍: Egyptian Journal of Forensic Sciences, the official publication of The International Association of Law and Forensic Sciences (IALFS), is an open access journal that publishes articles in the forensic sciences, pathology and clinical forensic medicine and its related specialities. The journal carries classic reviews, case studies, original research, hypotheses and learning points, offering critical analysis and scientific appraisal.
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