Prevalence and Predictors for Respiratory Viral Infections among Liver Disease Patients.

Jasmine Samal, Tushar Prabhakar, Manya Prasad, Nitiksha Rani, Bansidhar Tarai, Reshu Agarwal, Abhishek Padhi, Arvind Tomar, Rakhi Maiwall, Debajyoti Bhattacharyya, Manoj Kumar Sharma, Ekta Gupta
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Abstract

Aim and background: Respiratory viral infections (RVIs) cause significant hospitalizations every year. Also, RVIs caused by either influenza or noninfluenza group of viruses can have adverse outcomes, especially among immunosuppressed patients. Regular and timely supervision is needed for accurate etiological identification, to prevent inappropriate use of antibiotics in patients with nonbacterial etiology. This study aimed to identify the spectrum of RVIs and clinical characteristics among liver disease patients with influenza-like illness (ILI).

Materials and methods: In this study, medical records of patients with ILI, whose requests for respiratory viral testing came from September 2016 to December 2022 were retrospectively reviewed. Respiratory viruses were identified using FilmArray 2.0 respiratory panel (BioFire Diagnostics, USA).

Results: Of the 1,577 liver disease patients with ILI, the overall prevalence of RVI was 28% (n = 449). Infection by noninfluenza viruses (NIVs) was detected in 329 patients (73%), higher than those infected with influenza viruses. In multivariable logistic regression analysis, female gender [odds ratio (OR): 2.5, 95% confidence interval (CI): 1.5-4.2], infection with influenza B (OR: 3.3, 95% CI: 1.09-9.9) and decompensated cirrhosis (OR: 3.9, 95% CI: 1.7-8.5) were independent risk factors for mortality. Regarding seasonality, influenza peaked in monsoons and winters, whereas NIVs circulated throughout the year.

Conclusion: Overall, this study adds new knowledge regarding the incidence of RVI and the distribution of respiratory viral etiologies among liver disease patients with ILI. The findings highlight that female gender, decompensated cirrhosis, and influenza B infection are independently associated with poor clinical outcomes. Early etiological identification of viral causes of ILI could aid in an enhanced understanding of the prevalence of ILI and the timely management of the patients.

Clinical significance: Respiratory viral infections can cause severe illness in individuals with underlying liver disease. Accurate diagnosis and risk stratification is crucial in mitigating the adverse health effects.

How to cite this article: Samal J, Prabhakar T, Prasad M, et al. Prevalence and Predictors for Respiratory Viral Infections among Liver Disease Patients. Euroasian J Hepato-Gastroenterol 2023;13(2):108-114.

Abstract Image

Abstract Image

肝病患者呼吸道病毒感染的流行率和预测因素。
目的和背景:呼吸道病毒感染(RVI)每年都会导致大量患者住院治疗。此外,由流感或非流感病毒引起的呼吸道病毒感染也会造成不良后果,尤其是在免疫抑制患者中。为了准确识别病因,防止非细菌性病因患者不恰当地使用抗生素,需要进行定期和及时的监督。本研究旨在确定患有流感样疾病(ILI)的肝病患者的 RVI 范围和临床特征:本研究回顾性审查了 2016 年 9 月至 2022 年 12 月期间要求进行呼吸道病毒检测的 ILI 患者的病历。采用FilmArray 2.0呼吸系统检测板(美国BioFire诊断公司)对呼吸道病毒进行鉴定:在 1577 名患有 ILI 的肝病患者中,RVI 的总发病率为 28%(n = 449)。329名患者(73%)检测到非流感病毒(NIV)感染,高于流感病毒感染者。在多变量逻辑回归分析中,女性[几率比(OR):2.5,95% 置信区间(CI):1.5-4.2]、感染乙型流感(OR:3.3,95% CI:1.09-9.9)和失代偿期肝硬化(OR:3.9,95% CI:1.7-8.5)是导致死亡的独立风险因素。在季节性方面,流感在季风和冬季达到高峰,而非典型肺炎则全年流行:总之,这项研究为我们提供了有关肝病患者中呼吸道病毒感染发病率和呼吸道病毒病因分布的新知识。研究结果表明,女性性别、失代偿期肝硬化和乙型流感感染与不良临床预后密切相关。及早查明引起 ILI 的病毒病因有助于更好地了解 ILI 的流行情况并及时处理患者:临床意义:呼吸道病毒感染可导致患有基础肝病的患者出现严重疾病。如何引用本文?Samal J, Prabhakar T, Prasad M, et al.Euroasian J Hepato-Gastroenterol 2023;13(2):108-114.
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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