Cutaneous cryptococcosis in an adult male of sub-saharan origin.

Abstract

Cryptococcosis is caused by the inhalation of the desiccated encapsulated yeast or basidiospores, which are found in the environment. After the infectious particles reach the lungs, get disseminated hematogenously in various organs. Meningoencephalitis is one of the most common manifestations, especially in sub-Saharan Africa. The dermal lesions can be either primary due to the traumatic implantation of infectious propagule or secondary in patients with disseminated infection due to cryptococcus. The typical presentations of the cutaneous lesions are like umbilicated lesions of molluscum contagiosum. The dermal lesions can also be similar to Kaposi sarcoma or talaromycosis (formerly penicilliosis). Here, we present a 34-year-old male HIV-positive and antiretroviral therapy-naive. The patient had a very low CD4 cell count and a high viral load. The patient was referred to the dermatology clinic for multiple eruptions due to umbilicated skin colored lesions 3-5 mm in diameter on the nose.The patient was first treated for the opportunistic infection. The causes of the dermal umbilicated skin lesions are several. We must find out whether the dermal lesion is due to infection with a single organism or more than one. It can be colesional also. Punch biopsy, India ink, and culture on Sabouraud dextrose agar confirmed the diagnosis of Cryptococcus neoformans.