Synthesis of [3H]Org24598 using in-house prepared [3H]MeI
IF 0.9
4区 医学
Q4 BIOCHEMICAL RESEARCH METHODS
引用次数: 0
Abstract
The synthesis of tritium-labelled glycine transporter 1 inhibitor Org24598 is reported. Because of the instability of the Org24598 skeleton under hydrogenation conditions, a synthetic approach using an in-house prepared tritium-labelled alkylating agent ([3H]MeI, SA = 26.2 Ci/mmol) was employed. Alternative methods of labelling are discussed.
使用内部制备的[3 H]MeI 合成[3 H]Org24598 。
报告了氚标记的甘氨酸转运体 1 抑制剂 Org24598 的合成过程。由于 Org24598 骨架在氢化条件下不稳定，因此采用了一种使用内部制备的氚标记烷基化剂（[3 H]MeI, SA = 26.2 Ci/mmol）的合成方法。本文还讨论了其他标记方法。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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来源期刊
CiteScore
3.30
自引率
0.00%
发文量
57
审稿时长
1 months
期刊介绍：
The Journal of Labelled Compounds and Radiopharmaceuticals publishes all aspects of research dealing with labeled compound preparation and applications of these compounds. This includes tracer methods used in medical, pharmacological, biological, biochemical and chemical research in vitro and in vivo.
The Journal of Labelled Compounds and Radiopharmaceuticals devotes particular attention to biomedical research, diagnostic and therapeutic applications of radiopharmaceuticals, covering all stages of development from basic metabolic research and technological development to preclinical and clinical studies based on physically and chemically well characterized molecular structures, coordination compounds and nano-particles.
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