Outdoor time influences VIPR2 polymorphism rs2071623 to regulate axial length in Han Chinese children.

IF 1.8 3区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Vision Pub Date : 2023-11-05 eCollection Date: 2023-01-01

Xi He, Caixia Lin, Fengchuan Zhang, Sanguo Zhang, Mengtian Kang, Shifei Wei, He Li, Ningli Wang, Shi-Ming Li

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引用次数: 0

Abstract

Clinical relevance: Identification of individuals with a higher risk of developing refractive error under specific gene and environmental backgrounds, especially myopia, could enable more personalized myopic control advice for patients.

Background: Refractive error is a common disease that affects visual quality and ocular health worldwide. Its mechanisms have not been elaborated, although both genes and the environment are known to contribute to the process. Interactions between genes and the environment have been shown to exert effects on the onset of refractive error, especially myopia. Axial length elongation is the main characteristic of myopia development and could indicate the severity of myopia. Thus, the purpose of the study was to investigate the interaction between environmental factors and genetic markers of VIPR2 and their impact on spherical equivalence and axial length in a population of Han Chinese children.

Methods: A total of 1825 children aged 13~15 years in the Anyang Childhood Eye Study (ACES) were measured for cycloplegic autorefraction, axial length, and height. Saliva DNA was extracted for genotyping three single-nucleotide polymorphisms (SNPs) in the candidate gene (VIPR2). The median outdoor time (2 h/day) was used to categorize children into high and low exposure groups, respectively. Genetic quality control and linear and logistic regressions were performed. Generalized multifactor dimensional reduction (GMDR) was used to investigate gene-environment interactions.

Results: There were 1391 children who passed genetic quality control. Rs2071623 of VIPR2 was associated with axial length (T allele, β=-0.11 se=0.04 p=0.006), while SNP nominally interacted with outdoor time (T allele, β=-0.17 se=0.08 p=0.029). Rs2071623 in children with high outdoor exposure had a significant interaction effect on axial length (p=0.0007, β=-0.19 se=0.056) compared to children with low outdoor exposure. GMDR further suggested the existence of an interaction effect between outdoor time and rs2071623.

Conclusions: Rs2071623 within VIPR2 could interact with outdoor time in Han Chinese children. More outdoor exposure could enhance the protective effect of the T allele on axial elongation.

本刊更多论文

户外活动时间影响VIPR2多态性rs2071623调节汉族儿童的轴长

临床意义：识别在特定基因和环境背景下发生屈光不正（尤其是近视）风险较高的个体，可为患者提供更个性化的近视控制建议：背景：屈光不正是影响全球视觉质量和眼部健康的常见疾病。尽管已知基因和环境对这一过程都有影响，但其机制尚未得到阐明。基因与环境之间的相互作用已被证明会对屈光不正，尤其是近视的发生产生影响。轴长伸长是近视发展的主要特征，可显示近视的严重程度。因此，本研究旨在调查汉族儿童群体中环境因素与 VIPR2 遗传标记之间的相互作用及其对球面等值和轴长的影响：方法：在安阳儿童眼科研究（ACES）中，测量了 1825 名 13-15 岁儿童的屈光度、轴向长度和身高。提取唾液 DNA 对候选基因（VIPR2）中的三个单核苷酸多态性（SNPs）进行基因分型。户外活动时间的中位数（每天 2 小时）被用来将儿童分为高暴露组和低暴露组。进行遗传质量控制、线性回归和逻辑回归。采用广义多因素降维法（GMDR）研究基因与环境之间的相互作用：结果：1391 名儿童通过了基因质量控制。VIPR2的Rs2071623与轴长有关（T等位基因，β=-0.11 se=0.04 p=0.006），而SNP与户外活动时间有名义上的相互作用（T等位基因，β=-0.17 se=0.08 p=0.029）。与户外接触少的儿童相比，户外接触多的儿童的 Rs2071623 对轴长有显著的交互作用（p=0.0007，β=-0.19 se=0.056）。GMDR进一步表明，户外时间与rs2071623之间存在交互效应：结论：在汉族儿童中，VIPR2 中的 Rs2071623 与户外活动时间之间存在相互作用。结论：在汉族儿童中，VIPR2 中的 Rs2071623 可与户外活动时间相互作用，更多的户外活动可增强 T 等位基因对轴伸长的保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Vision 生物-生化与分子生物学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Molecular Vision is a peer-reviewed journal dedicated to the dissemination of research results in molecular biology, cell biology, and the genetics of the visual system (ocular and cortical). Molecular Vision publishes articles presenting original research that has not previously been published and comprehensive articles reviewing the current status of a particular field or topic. Submissions to Molecular Vision are subjected to rigorous peer review. Molecular Vision does NOT publish preprints. For authors, Molecular Vision provides a rapid means of communicating important results. Access to Molecular Vision is free and unrestricted, allowing the widest possible audience for your article. Digital publishing allows you to use color images freely (and without fees). Additionally, you may publish animations, sounds, or other supplementary information that clarifies or supports your article. Each of the authors of an article may also list an electronic mail address (which will be updated upon request) to give interested readers easy access to authors.