Proteomics provides insights into the theranostic potential of extracellular vesicles.

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Morteza Abyadeh, Mehdi Alikhani, Mehdi Mirzaei, Vivek Gupta, Faezeh Shekari, Ghasem Hosseini Salekdeh
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引用次数: 0

Abstract

Extracellular vesicles (EVs) encompass a diverse range of membranous structures derived from cells, including exosomes and microvesicles. These vesicles are present in biological fluids and play vital roles in various physiological and pathological processes. They facilitate intercellular communication by enabling the exchange of proteins, lipids, and genetic material between cells. Understanding the cellular processes that govern EV biology is essential for unraveling their physiological and pathological functions and their potential clinical applications. Despite significant advancements in EV research in recent years, there is still much to learn about these vesicles. The advent of improved mass spectrometry (MS)-based techniques has allowed for a deeper characterization of EV protein composition, providing valuable insights into their roles in different physiological and pathological conditions. In this chapter, we provide an overview of proteomics studies conducted to identify the protein contents of EVs, which contribute to their therapeutic and pathological features. We also provided evidence on the potential of EV proteome contents as biomarkers for early disease diagnosis, progression, and treatment response, as well as factors that influence their composition. Additionally, we discuss the available databases containing information on EV proteome contents, and finally, we highlight the need for further research to pave the way toward their utilization in clinical settings.

蛋白质组学有助于深入了解细胞外囊泡的治疗潜力。
细胞外囊泡(EVs)包括来自细胞的各种膜结构,其中包括外泌体和微囊泡。这些囊泡存在于生物液体中,在各种生理和病理过程中发挥着重要作用。它们可以在细胞间交换蛋白质、脂质和遗传物质,从而促进细胞间的交流。要揭示 EV 的生理和病理功能及其潜在的临床应用,了解支配 EV 生物学的细胞过程至关重要。尽管近年来对 EV 的研究取得了重大进展,但关于这些囊泡仍有许多知识需要了解。基于质谱(MS)技术的改进使人们能够更深入地鉴定 EV 蛋白质的组成,为了解它们在不同生理和病理条件下的作用提供了宝贵的见解。在本章中,我们概述了蛋白质组学研究的情况,这些研究旨在确定EVs中的蛋白质含量,这些蛋白质含量有助于EVs的治疗和病理特征。我们还提供了有关 EV 蛋白质组内容作为早期疾病诊断、进展和治疗反应生物标志物的潜力以及影响其组成的因素的证据。此外,我们还讨论了包含 EV 蛋白质组内容信息的可用数据库,最后,我们强调了进一步研究的必要性,以便为在临床环境中利用它们铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advances in protein chemistry and structural biology
Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
7.40
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.
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