Changes in the fecal microbiota of breast cancer patients based on 16S rRNA gene sequencing: a systematic review and meta-analysis

Biqing Luan, Fei Ge, Xingjia Lu, Zhiqiang Li, Hong Zhang, Jingxuan Wu, Qizhi Yang, Liang Chen, Wenzhu Zhang, Wenlin Chen
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Abstract

Purpose

Breast cancer (BC) is a devastating disease for women. Microbial influences may be involved in the development and progression of breast cancer. This study aimed to investigate the difference in intestinal flora abundance between breast cancer patients and healthy controls (HC) based on previous 16S ribosomal RNA (rRNA) gene sequencing results, which have been scattered and inconsistent in previous studies.

Materials and methods

In agreement with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), we searched for pertinent literature in Pubmed, Embase, Cochrane Library, and Web of Science databases from build until February 1, 2023. Relative abundance, diversity of intestinal microflora by level, microbial composition, community structure, diversity index, and other related data were extracted. We used a fixed or random effects model for data analysis. We also conducted funnel plot analysis, sensitivity analysis, Egger's, and Begg’s tests to assess the bias risk.

Results

A total of ten studies involving 734 BC patients were enrolled. It was pointed out that there were significant differences in the Chao index between BC and HC in these studies [SMD = − 175.44 (95% CI − 246.50 to − 104.39)]. The relative abundance of Prevotellaceae [SMD = − 0.27 (95% CI − 0.39 to − 0.15)] and Bacteroides [SMD = 0.36 (95% CI 0.23–0.49)] was significantly different. In the included articles, the relative abundance of Prevotellaceae, Ruminococcus, Roseburia inulinivorans, and Faecalibacterium prausnitzii decreased in BC. Accordingly, the relative richness of Erysipelotrichaceae was high in BC.

Conclusions

This observational meta-analysis revealed that the changes in gut microbiota were correlated with BC, and the changes in some primary fecal microbiota might affect the beginning of breast cancer.

Abstract Image

基于 16S rRNA 基因测序的乳腺癌患者粪便微生物群变化:系统综述和荟萃分析
目的乳腺癌(BC)对女性来说是一种毁灭性疾病。微生物的影响可能与乳腺癌的发生和发展有关。本研究旨在根据以往研究中分散且不一致的 16S 核糖体 RNA(rRNA)基因测序结果,调查乳腺癌患者与健康对照组(HC)之间肠道菌群丰度的差异。材料与方法根据系统综述和荟萃分析首选报告项目(PRISMA),我们在 Pubmed、Embase、Cochrane Library 和 Web of Science 数据库中检索了从建立到 2023 年 2 月 1 日的相关文献。提取了相对丰度、各级肠道微生物菌群的多样性、微生物组成、群落结构、多样性指数和其他相关数据。我们采用固定效应或随机效应模型进行数据分析。我们还进行了漏斗图分析、敏感性分析、Egger's 检验和 Begg's 检验,以评估偏倚风险。研究指出,在这些研究中,BC和HC的Chao指数存在显著差异[SMD = - 175.44 (95% CI - 246.50 to - 104.39)]。前鞭毛菌科(Prevotellaceae)[SMD = - 0.27 (95% CI - 0.39 to - 0.15)]和乳杆菌(Bacteroides)[SMD = 0.36 (95% CI 0.23-0.49)]的相对丰度存在显著差异。在所收录的文章中,前鞭毛菌科(Prevotellaceae)、反刍球菌(Ruminococcus)、Roseburia inulinivorans 和普氏粪杆菌(Faecalibacterium prausnitzii)的相对丰度在 BC 中有所下降。结论这项观察性荟萃分析表明,肠道微生物群的变化与乳腺癌相关,一些原发性粪便微生物群的变化可能会影响乳腺癌的发病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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