Cytotoxicity of Turmeric Extract (Curcuma longa linn.) on BHK21 Fibroblast Cells

International Journal of Science and Society Pub Date : 2024-01-05 DOI:10.54783/ijsoc.v6i1.1005

Nadya Fithrie Azzahra, Retno Indrawati, I. Diyatri

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Abstract

Wound healing is the process of recovery from injury to stop bleeding, and fibroblasts play a crucial role in the healing process and contribute to the regeneration of periodontal tissue. Turmeric extract (Curcuma longa linn.) is an alternative treatment that uses natural ingredients with antibacterial, antioxidant, and anti-inflammatory properties. The aim of this study is to demonstrate the toxicity of turmeric extract (Curcuma longa linn.) on BHK21 fibroblast cells. Turmeric extract (Curcuma longa linn.) was administered at concentrations of 100%, 50%, 25%, 12.5%, 6.25%, 3.12%, 1.56%, and 0.78% to BHK-21 fibroblast cells, and its cytotoxicity was tested using the MTT Assay. The research results show that the percentage viability of fibroblast cells decreases successively with concentrations of 100%, 50%, 25%, 12.5%, 6.25%, 3.12%, 1.56%, and 0.78%, with the highest percentage at a turmeric extract concentration of 0.78% and the lowest at a concentration of 100%. The conclusion of this study is that turmeric extract (Curcuma longa linn.) is not cytotoxic to BHK-21 fibroblast cells at concentrations of 0.78%, 1.56%, and 3.12%.

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姜黄提取物（Curcuma longa linn.）对 BHK21 成纤维细胞的细胞毒性

伤口愈合是从受伤到止血的恢复过程，而成纤维细胞在愈合过程中起着至关重要的作用，有助于牙周组织的再生。姜黄提取物（Curcuma longa linn.）是一种使用具有抗菌、抗氧化和抗炎特性的天然成分的替代治疗方法。本研究旨在证明姜黄提取物对 BHK21 成纤维细胞的毒性。姜黄提取物（Curcuma longa linn.）在 BHK-21 成纤维细胞中的浓度分别为 100%、50%、25%、12.5%、6.25%、3.12%、1.56% 和 0.78%，并使用 MTT 分析法检测其细胞毒性。研究结果表明，姜黄提取物浓度为 100%、50%、25%、12.5%、6.25%、3.12%、1.56% 和 0.78%时，成纤维细胞的存活率依次下降，姜黄提取物浓度为 0.78%时，成纤维细胞的存活率最高，浓度为 100%时，成纤维细胞的存活率最低。本研究的结论是，姜黄提取物（Curcuma longa linn.）在浓度为 0.78%、1.56% 和 3.12% 时对 BHK-21 成纤维细胞无细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International Journal of Science and Society

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