QUANTITATIVE ANALYSIS OF DEXTROMETHORPHAN-HBr, GUAIFENESIN, AND DIPHENHYDRAMINE-HCl IN TABLET DOSAGE FORM BY RATIO DIFFERENCE SPECTROPHOTOMETRY METHOD

Q2 Pharmacology, Toxicology and Pharmaceutics

International Journal of Applied Pharmaceutics Pub Date : 2024-01-07 DOI:10.22159/ijap.2024v16i1.49218

R. E. Tarigan, Muhammad Andry, Annisa Tifany ZULMI MARPAUNG, Muhammad Amin Nasution, Muhammad Fauzan Lubis

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引用次数: 0

Abstract

Objective: This study aims to develop a spectrophotometric method with the Ratio Difference method using ethanol pro analysis solvent to obtain the results of Dextromethorphan Hydrobromide (HBr) levels of Guaifenesin and Diphenhydramine Hydrochloride (HCl) in tablets. Methods: The Ratio Difference Sprctrophotography method involves dividing the mixture spectrum by the standard spectrum of each analyte and reducing the ratio to obtain a spectrum that does not depend on the concentration of the analyte used as a divider and can directly determine the levels of Dextromethorphan HBr, Guaifenesin, and Diphenhydramine HCl in the range 200-400 nm wavelength using experimentally calculated absorbance. Results: The maximum wavelengths of Dextromethorphan HBr, Guaifenesin, and Diphenhydramine HCl were obtained at 278 nm, 273 nm, and 252 nm, respectively. The average % accuracy obtained was 99.60% for Dextromethorphan HBr, 98.98% for Guaifenesin, and 100.32% for Diphenhydramine HCl in dosage forms. Conclusion: This method was successfully applied with simultaneous estimation to determine Dextromethorphan HBr, Guaifenesin, and Diphenhydramine HCl levels in tablet preparations and met the validation requirements.

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用比差荧光光度法定量分析片剂中的地塞米松-氢溴酸盐、愈创木酚素和二苯二胺-盐酸盐

研究目的本研究旨在开发一种使用乙醇作为分析溶剂的比值差分光光度法，以获得片剂中氢溴酸右美沙芬（HBr）、愈创木酚（Guaifenesin）和盐酸苯海拉明（HCl）的含量结果：比率差分光度法是将混合物光谱除以各分析物的标准光谱，然后减小比率，得到的光谱不依赖于作为除数的分析物的浓度，可以直接利用实验计算出的吸光度测定 200-400 nm 波长范围内右美沙芬、愈创木酚和盐酸苯海拉明的含量：右美沙芬、愈创木酚和盐酸苯海拉明的最大波长分别为 278 nm、273 nm 和 252 nm。右美沙芬 HBr、愈创木酚素和盐酸苯海拉明的平均准确度分别为 99.60%、98.98%和 100.32%：该方法成功地同时测定了片剂中右美沙芬 HBr、愈创木酚素和盐酸苯海拉明的含量，符合验证要求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Applied Pharmaceutics Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

CiteScore

1.40

自引率

0.00%

发文量

219

期刊介绍： International Journal of Applied Pharmaceutics (Int J App Pharm) is a peer-reviewed, bimonthly (onward March 2017) open access journal devoted to the excellence and research in the pure pharmaceutics. This Journal publishes original research work that contributes significantly to further the scientific knowledge in conventional dosage forms, formulation development and characterization, controlled and novel drug delivery, biopharmaceutics, pharmacokinetics, molecular drug design, polymer-based drug delivery, nanotechnology, nanocarrier based drug delivery, novel routes and modes of delivery; responsive delivery systems, prodrug design, development and characterization of the targeted drug delivery systems, ligand carrier interactions etc. However, the other areas which are related to the pharmaceutics are also entertained includes physical pharmacy and API (active pharmaceutical ingredients) analysis. The Journal publishes original research work either as a Original Article or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication in the Journal.