Exploring avenues for Alzheimer’s drugs: current status and future outlook

Abstract

Alzheimer’s disease (AD) is a progressive neurological disease that causes cognitive impairment in old aged persons. It is the cause of a wide spectrum of neurodegenerative disturbances including tauopathies, which are responsible for progressive neuronal degeneration and impaired cognitive functions. Although drug discovery researchers and pharmaceutical companies are meticulously working to develop novel drugs for AD, establishing their safety and efficacy proofs are major challenges for them. In this review, we have discussed about AD and its causes mainly focusing on molecular targets with their physiological and pathophysiological roles, therapeutic approaches, and their future perspectives. We have compiled the information about novel and promising drug targets and lead data bases that will help to select appropriate target and design novel drug molecules for the treatment of Alzheimer.