The effect of vitamin K supplementation on cardiovascular risk factors: a systematic review and meta-analysis

IF 2.4 Q3 NUTRITION & DIETETICS
Qiu-Yan Zhao, Qiu Li, Minoo Hasan Rashedi, Mohammadhassan Sohouli, Pejman Rohani, Periyannan Velu
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Abstract

Abstract Cardiovascular disease (CVD) is one of the most important diseases which controlling its related risk factors, such as metabolic and inflammatory biomarkers, is necessary because of the increased mortality risk of that. The aim of our meta-analysis is to reveal the general effect of vitamin K supplementation on its related risk factors. Original databases were searched using standard keywords to identify all randomized clinical trials (RCTs) investigating the effects of vitamin K on CVD. Pooled weighted mean difference (WMD) and 95 % confidence intervals (95 % CI) were achieved by random-model effect analysis for the best estimation of outcomes. The statistical heterogeneity was determined using the Cochran's Q test and I2 statistics. Seventeen studies were included in this systematic review and meta-analysis. The pooled findings showed that vitamin K supplementation can reduce homeostatic model assessment insulin resistance (HOMA-IR) (WMD: −0⋅24, 95 % CI: −0⋅49, −0⋅02, P = 0⋅047) significantly compared to the placebo group. However, no significant effect was observed on other outcomes. Subgroup analysis showed a significant effect of vitamin K2 supplementation compared to vitamin K1 supplementation on HOMA-IR. However, no significant effect was observed on other variables. Also, subgroup analysis showed no potential effect of vitamin K supplementation on any outcome and omitting any articles did not affect the final results. We demonstrated that supplementation with vitamin K has no effect on anthropometrics indexes, CRP, glucose metabolism, and lipid profile factors except HOMA-IR.
维生素 K 补充剂对心血管风险因素的影响:系统回顾和荟萃分析
摘要 心血管疾病(CVD)是最重要的疾病之一,控制其相关风险因素(如代谢和炎症生物标志物)是必要的,因为这会增加死亡风险。我们的荟萃分析旨在揭示维生素 K 补充剂对相关风险因素的总体影响。我们使用标准关键词检索了原始数据库,以确定所有研究维生素 K 对心血管疾病影响的随机临床试验(RCT)。通过随机模型效应分析得出汇总加权平均差(WMD)和95%置信区间(95% CI),以获得对结果的最佳估计。统计异质性采用 Cochran's Q 检验和 I2 统计。本次系统综述和荟萃分析共纳入 17 项研究。汇总结果显示,与安慰剂组相比,维生素 K 补充剂可显著降低胰岛素抵抗稳态模型评估(HOMA-IR)(WMD:-0⋅24,95 % CI:-0⋅49,-0⋅02,P = 0⋅047)。但对其他结果没有观察到明显影响。亚组分析显示,与维生素 K1 补充剂相比,维生素 K2 补充剂对 HOMA-IR 有明显影响。但对其他变量未观察到明显影响。此外,亚组分析表明,维生素 K 补充剂对任何结果都没有潜在影响,省略任何文章都不会影响最终结果。我们的研究表明,补充维生素 K 对人体测量指标、CRP、糖代谢和除 HOMA-IR 以外的血脂概况因素没有影响。
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来源期刊
Journal of Nutritional Science
Journal of Nutritional Science NUTRITION & DIETETICS-
CiteScore
3.00
自引率
0.00%
发文量
91
审稿时长
7 weeks
期刊介绍: Journal of Nutritional Science is an international, peer-reviewed, online only, open access journal that welcomes high-quality research articles in all aspects of nutrition. The underlying aim of all work should be, as far as possible, to develop nutritional concepts. JNS encompasses the full spectrum of nutritional science including public health nutrition, epidemiology, dietary surveys, nutritional requirements, metabolic studies, body composition, energetics, appetite, obesity, ageing, endocrinology, immunology, neuroscience, microbiology, genetics, molecular and cellular biology and nutrigenomics. JNS welcomes Primary Research Papers, Brief Reports, Review Articles, Systematic Reviews, Workshop Reports, Letters to the Editor and Obituaries.
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