Metastatic ovarian high grade serous carcinoma with intestinal and omental deposits and marked clinicopathological treatment response in right ovary: A rare case report

Kafil Akhtar, Z. Hashmi, Sara Fatima Aslam, Adiba Khan
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Abstract

High grade serous ovarian cancer is the most common form of ovarian cancer which is frequently fatal, as it is commonly diagnosed after substantial metastasis has already occurred. The present study reports a 65 years old woman with postmenopausal bleeding for 3 months. CE-MRI revealed malignant right ovarian lesion with broad ligament fibroid with malignant degeneration. Histopathological examination was consistent with high grade serous carcinoma of right ovary. Patient then received 6 cycles of chemotherapy. After 4 months, she developed abdominal discomfort and backache for which a repeat CE-MRI was performed which showed a heterogeneity in the right adnexa with no markedly appreciable abnormal foci in the right ovary. Subsequently the patient underwent transabdominal hysterectomy with bilateral salpingo-oophorectomy with right hemicolectomy and omentectomy. Microscopic examination of intestine and omentum showed infiltration by tumor cells. A final diagnosis of metastatic high grade carcinoma of ovary with intestinal and omental deposits was given.
右侧卵巢转移性卵巢高级别浆液性癌伴肠和网膜沉积,临床病理治疗反应明显:罕见病例报告
高级别浆液性卵巢癌是卵巢癌中最常见的一种,由于通常在发生实质性转移后才被诊断出来,因此常常是致命的。本研究报告了一名绝经后出血 3 个月的 65 岁女性。CE-MRI 显示右侧卵巢恶性病变,伴有恶性变性的阔韧带纤维瘤。组织病理学检查符合右卵巢高级别浆液性癌。患者随后接受了 6 个周期的化疗。4 个月后,她出现腹部不适和背痛,因此再次进行了 CE-MRI 检查,结果显示右侧附件存在异质性,右侧卵巢没有明显的异常病灶。随后,患者接受了经腹子宫切除术、双侧输卵管切除术、右半结肠切除术和卵巢切除术。肠道和网膜的显微镜检查显示肿瘤细胞浸润。最终诊断为卵巢转移性高级别癌伴肠道和网膜沉积。
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