Disruptive consequences of monosodium glutamate on male reproductive function: A review

IF 2.9 Q2 TOXICOLOGY
David Tolulope OLUWOLE , Oladipupo`Samuel EBIWONJUMI , Lydia Oluwatoyin AJAYI , Olubunmi Dupe ALABI , Victor AMOS , Grace AKANBI , Wale Johnson ADEYEMI , Ayodeji Folorunsho AJAYI
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Abstract

Monosodium glutamate (MSG) is one of the most extensively used flavour enhancers worldwide. Although it is widely regarded as a safe food additive with no recommended daily dosage, its over-consumption has been associated with notably pathophysiological events in various tissues and organs of the body. Previous studies have reported of the neuro- cardio- and hepato- toxic effects of its excessive exposure. Moreover, the food additive instigates metabolic dysfunction. It has been established that MSG damages male reproductive accessory organs like prostate glands and epididymis. In addition, it impairs serum enzymatic activities and serum levels of testosterone, gonadotropin-releasing hormone, luteinizing hormone and cholesterol. Reduced sperm count, sperm motility, sperm morphology, and sperm viability, imbalances in male reproductive hormones, alongside alteration in the histoarchitecture of the testes and other male reproductive tissues have also been connected with excessive exposure to MSG. Literature reports affirm the link between the over-consumption of MSG and reproductive organ weight and male sexual behaviour. This review article addresses the multi-systemic effects of exposure to MSG and the possible mechanism of action of the compound with a focus on the negative implications of the food additive on male reproductive functions and the possible role of natural antioxidants in male reproductive functions. carefully selected keywords were used during the literature search to gather credible and up-to-date information about the subject matter.

Abstract Image

谷氨酸钠对男性生殖功能的干扰后果:综述
谷氨酸一钠(味精)是全球使用最广泛的增味剂之一。虽然人们普遍认为味精是一种安全的食品添加剂,没有推荐的每日用量,但过量摄入味精与人体各组织和器官的病理生理事件有明显关联。以往的研究报告显示,过量摄入这种物质会对神经、心血管和肝脏产生毒性影响。此外,这种食品添加剂还会引起新陈代谢功能紊乱。已证实味精会损害男性生殖附属器官,如前列腺和附睾。此外,味精还会损害血清酶活性和血清中的睾酮、促性腺激素释放激素、黄体生成素和胆固醇水平。精子数量、精子活力、精子形态和精子存活率降低,男性生殖激素失衡,以及睾丸和其他男性生殖组织的组织结构改变,也与过量接触味精有关。文献报道肯定了过量摄入味精与生殖器官重量和男性性行为之间的联系。这篇综述文章探讨了接触味精的多系统影响以及这种化合物可能的作用机制,重点是这种食品添加剂对男性生殖功能的负面影响以及天然抗氧化剂在男性生殖功能中可能发挥的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Research in Toxicology
Current Research in Toxicology Environmental Science-Health, Toxicology and Mutagenesis
CiteScore
4.70
自引率
3.00%
发文量
33
审稿时长
82 days
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