Targeting Protein Phosphatases for the Treatment of Chronic Liver Disease.

IF 3 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug targets Pub Date : 2024-01-01 DOI:10.2174/0113894501278886231221092522

Yi-Ming Li, Hong-Wei He, Na Zhang

引用次数: 0

Abstract

There exists a huge number of patients suffering from chronic liver disease worldwide. As a disease with high incidence and mortality worldwide, strengthening the research on the pathogenesis of chronic liver disease and the development of novel drugs is an important issue related to the health of all human beings. Phosphorylation modification of proteins plays a crucial role in cellular signal transduction, and phosphatases are involved in the development of liver diseases. Therefore, this article summarized the important role of protein phosphatases in chronic liver disease with the aim of facilitating the development of drugs targeting protein phosphatases for the treatment of chronic liver disease.

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以蛋白磷酸酶为靶点治疗慢性肝病。

全世界有大量的慢性肝病患者。作为世界范围内发病率和死亡率较高的疾病，加强对慢性肝病发病机理的研究和新型药物的开发是关系到全人类健康的重要课题。蛋白质的磷酸化修饰在细胞信号传导中起着至关重要的作用，而磷酸酶与肝病的发生发展有关。因此，本文总结了蛋白磷酸酶在慢性肝病中的重要作用，旨在促进针对蛋白磷酸酶治疗慢性肝病药物的开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug targets 医学-药学

CiteScore

6.20

自引率

0.00%

发文量

127

审稿时长

3-8 weeks

期刊介绍： Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication mini- & full-length review articles and drug clinical trial studies. As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.