The Radioprotective Effect of LBP on Neurogenesis and Cognition after Acute Radiation Exposure.

IF 1.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Current radiopharmaceuticals Pub Date : 2024-01-01 DOI:10.2174/0118744710274008231220055033

Gang Yin, Qinqi Wang, Tongtong Lv, Yifan Liu, Xiaochun Peng, Xianqin Zeng, Jiangrong Huang

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引用次数: 0

Abstract

Background: Radiation exposure has been linked to the development of brain damage and cognitive impairment, but the protective effect and mechanism of Lycium barbarum pills (LBP) on radiation-induced neurological damage remains to be clarified.

Methods: Behavioral tests and immunohistochemical studies were conducted to evaluate the protective effects of LBP extract (10 g/kg orally daily for 4 weeks) against radiation-induced damage on neurogenesis and cognitive function in Balb/c mice exposed to 5.5 Gy X-ray acute radiation.

Results: The results showed that the LBP extract significantly improved body weight loss, locomotor activity and spatial learning and memory. Immunohistochemical tests revealed that the LBP extract prevented the loss of proliferating cells, newly generated neurons and interneurons, especially in the subgranular area of the dentate gyrus.

Conclusion: The findings suggest that LBP is a potential neuroprotective drug for mitigating radiation-induced neuropsychological disorders.

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枸杞多糖对急性辐射暴露后神经发生和认知的辐射保护作用

背景：辐照与脑损伤和认知障碍的发生有关，但枸杞丸（LBP）对辐射诱导的神经损伤的保护作用和机制仍有待明确：方法：通过行为测试和免疫组化研究，评估枸杞子提取物（每天口服 10 克/千克，连续 4 周）对暴露于 5.5 Gy X 射线急性辐射的 Balb/c 小鼠神经发生和认知功能损伤的保护作用：结果表明，枸杞子提取物能明显改善小鼠的体重减轻、运动活性、空间学习和记忆能力。免疫组化检测显示，枸杞子提取物可防止增殖细胞、新生成神经元和中间神经元的损失，尤其是在齿状回的粒下区：研究结果表明，枸杞多糖是一种潜在的神经保护药物，可减轻辐射引起的神经心理障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current radiopharmaceuticals PHARMACOLOGY & PHARMACY-

CiteScore

3.20

自引率

4.30%

发文量