Control strategy for biopharmaceutical production by model predictive control

IF 2.5 3区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Touraj Eslami, Alois Jungbauer
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引用次数: 0

Abstract

The biopharmaceutical industry is rapidly advancing, driven by the need for cutting-edge technologies to meet the growing demand for life-saving treatments. In this context, Model Predictive Control (MPC) has emerged as a promising solution to address the complexity of modern biopharmaceutical production processes. Its ability to optimize operations and ensure consistent product yields has made it an attractive option for manufacturers in this sector. Furthermore, MPC's alignment with the Process Analytical Technology (PAT) initiative provides an additional layer of assurance, facilitating real-time monitoring and enabling swift adjustments to maintain process integrity. This comprehensive review delves into the various applications of MPC, ranging from robust control to stochastic model predictive control, thereby equipping biotechnologists and process engineers with a powerful toolset. By harnessing the capabilities of MPC, as elucidated in this review, manufacturers can confidently navigate the intricate bioprocessing landscape and unlock this approach's full potential in their production processes.

Abstract Image

利用模型预测控制的生物制药生产控制策略。
生物制药行业正在迅速发展,其动力来自于对尖端技术的需求,以满足人们对挽救生命的治疗方法日益增长的需求。在这种情况下,模型预测控制(MPC)已成为应对现代生物制药生产流程复杂性的一种有前途的解决方案。MPC 能够优化操作并确保产品产量的一致性,这使其成为该行业制造商的一个极具吸引力的选择。此外,MPC 与工艺分析技术 (PAT) 计划的结合提供了额外的保障,有利于实时监控和快速调整,以保持工艺的完整性。这篇综合评论深入探讨了 MPC 的各种应用,从稳健控制到随机模型预测控制,从而为生物技术专家和工艺工程师提供了一个强大的工具集。通过利用本综述中阐明的 MPC 功能,制造商可以自信地在错综复杂的生物加工领域中游刃有余,并在其生产流程中充分释放这种方法的潜力。
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来源期刊
Biotechnology Progress
Biotechnology Progress 工程技术-生物工程与应用微生物
CiteScore
6.50
自引率
3.40%
发文量
83
审稿时长
4 months
期刊介绍: Biotechnology Progress , an official, bimonthly publication of the American Institute of Chemical Engineers and its technological community, the Society for Biological Engineering, features peer-reviewed research articles, reviews, and descriptions of emerging techniques for the development and design of new processes, products, and devices for the biotechnology, biopharmaceutical and bioprocess industries. Widespread interest includes application of biological and engineering principles in fields such as applied cellular physiology and metabolic engineering, biocatalysis and bioreactor design, bioseparations and downstream processing, cell culture and tissue engineering, biosensors and process control, bioinformatics and systems biology, biomaterials and artificial organs, stem cell biology and genetics, and plant biology and food science. Manuscripts concerning the design of related processes, products, or devices are also encouraged. Four types of manuscripts are printed in the Journal: Research Papers, Topical or Review Papers, Letters to the Editor, and R & D Notes.
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