Health-Related Quality of Life and Economic Burden Among Hospitalized Children with Hand, Foot, and Mouth Disease: A Multiregional Study in China.

IF 2 Q2 ECONOMICS
PharmacoEconomics Open Pub Date : 2024-05-01 Epub Date: 2024-01-09 DOI:10.1007/s41669-023-00468-1
Ting Zhou, Hongfei Hu, Junyang Gao, Hongjie Yu, Mark Jit, Pei Wang
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引用次数: 0

Abstract

Background: Hand, foot, and mouth disease (HFMD) is an infectious disease with high morbidity and mortality rates among children under 5 years old. This study aimed to explore the health-related quality of life (HRQOL), economic burden, and related influencing factors among Chinese HFMD patients.

Methods: From January to October 2019, a longitudinal cohort study of 296 hospitalized patients (≤ 5 years old) with HFMD and their guardians was conducted using the proxy version of the 5-level EQ-5D-Y (EQ-5D-Y-5L, Y-5L) in face-to-face interviews in Shanghai, Zhengzhou, and Kunming, representing three regions with different economic development levels. Multiple linear regression was used to explore the factors associated with HRQOL and costs.

Results: The mean Y-5L health utility score (HUS) (standard deviation, SD), and visual analogue scale (VAS) score (SD) were 0.730 (0.140) and 60.33 (16.52) at admission and increased to 0.920 (0.120) and 89.95 (11.88) at discharge, respectively. The children from Shanghai had the lowest HUSs at admission and had the best health improvement. The mean hospitalization cost and total cost were 4037 CNY and 5157 CNY, respectively. The children from Shanghai had the highest hospitalization cost (4559 CNY) and total cost (5491 CNY). Multiple regression analysis suggested that medical insurance status, type of employment, residence type, and religious status were significantly associated with the baseline HUS and improvement in the HUS after treatment. Region, loss of work time, and length of stay had a significant impact on the hospitalization cost and total cost.

Conclusion: Our findings demonstrate that HFMD could lead to poor HRQOL and the economic burden varies in different regions in China. Many pediatric patients still have physical or mental health problems shortly after treatment.

手足口病住院患儿的健康相关生活质量和经济负担:中国多地区研究》。
背景:手足口病(HFMD)是一种5岁以下儿童发病率和死亡率较高的传染病。本研究旨在探讨中国手足口病患者的健康相关生活质量(HRQOL)、经济负担及相关影响因素:2019年1月至10月,在代表不同经济发展水平的上海、郑州和昆明三个地区,采用5级EQ-5D-Y(EQ-5D-Y-5L,Y-5L)替代版,对296名住院的手足口病患者(≤5岁)及其监护人进行了面对面访谈的纵向队列研究。结果显示,Y-5L健康效用的平均值为0.5,而EQ-5D-Y-5L健康效用的平均值为0.5:入院时,Y-5L健康效用评分(HUS)(标准差,SD)和视觉模拟量表(VAS)评分(SD)的平均值分别为0.730(0.140)和60.33(16.52),出院时分别增至0.920(0.120)和89.95(11.88)。上海患儿入院时的 HUSs 最低,健康改善情况最好。平均住院费用和总费用分别为 4037 元和 5157 元。上海患儿的住院费用(4559 元)和总费用(5491 元)最高。多元回归分析表明,医疗保险状况、就业类型、居住类型和宗教信仰与基线 HUS 和治疗后 HUS 的改善有显著相关性。地区、工作时间损失和住院时间对住院费用和总费用有显著影响:我们的研究结果表明,手足口病可导致不良的 HRQOL,其经济负担在中国不同地区存在差异。许多儿童患者在治疗后不久仍有身体或精神健康问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.50
自引率
0.00%
发文量
64
审稿时长
8 weeks
期刊介绍: PharmacoEconomics - Open focuses on applied research on the economic implications and health outcomes associated with drugs, devices and other healthcare interventions. The journal includes, but is not limited to, the following research areas:Economic analysis of healthcare interventionsHealth outcomes researchCost-of-illness studiesQuality-of-life studiesAdditional digital features (including animated abstracts, video abstracts, slide decks, audio slides, instructional videos, infographics, podcasts and animations) can be published with articles; these are designed to increase the visibility, readership and educational value of the journal’s content. In addition, articles published in PharmacoEconomics -Open may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand important medical advances.All manuscripts are subject to peer review by international experts. Letters to the Editor are welcomed and will be considered for publication.
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