Brain-derived Neurotrophic Factor Level and Gene Polymorphism as Risk Factors for Depression in Patients with type 2 Diabetes Mellitus- A Case-Controlled Study.

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM
Hany Hammad, Inass Shaltout, Mai M Fawzy, Laila A Rashed, Noha A Mahfouz, Tarek S Abdelaziz
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Abstract

Background: Diabetes mellitus and depression are comorbidities that can be caused by each other. Brain-derived neurotrophic factor (BDNF) functions as a neuronal growth factor. It maintains the functional integrity of the nervous system.

Aim: To study the possible association between BDNF levels and gene polymorphism with depression in patients diagnosed with type 2 diabetes mellitus.

Methods: The Elisa technique measured BDNF, and rs6265 gene polymorphism was detected using real-time PCR. Depression was assessed utilizing a clinical interview tool designed to establish the diagnosis of depression and differentiate it from other psychiatric diseases.

Results: BDNF levels were significantly lower in patients with type 2 diabetes mellitus and symptoms of depression than in patients with type 2 diabetes mellitus and no symptoms of depression (82.6±16.1. Vs 122± 17.47, p˂ 0.001). There was a statistically significant difference in BDNF levels in patients with diabetes among the three genotypes of the BDNF gene (p-value < 0.001). Val/ Val carriers had the highest serum BDNF levels, and Met/ Met carriers had the lowest serum BDNF levels. Subgroup analysis showed statistically significant genotype-related differences in serum BDNF levels among the three subgroups in the Depression group. Val/ Val carriers had the highest serum BDNF levels, and Met/ Met carriers had the lowest serum BDNF levels. BDNF Val66Met polymorphism had no significant association with the presence of depression, yet there was a trend towards significance (p = 0.05) Conclusion: In this pilot, Low levels of BDNF were associated with depression in patients with type 2 diabetes. Carriers of the Met/ Met allele have the lowest serum BDNF levels. Multicenter studies with more participants are required.

脑源性神经营养因子水平和基因多态性是 2 型糖尿病患者抑郁的风险因素--一项病例对照研究。
背景:糖尿病和抑郁症是可能互为因果的合并症。脑源性神经营养因子(BDNF)是一种神经元生长因子,可维持神经系统功能的完整性。目的:研究确诊为 2 型糖尿病患者的 BDNF 水平和基因多态性与抑郁症之间可能存在的关联:方法:采用Elisa技术测量BDNF,并采用实时PCR技术检测rs6265基因多态性。采用临床访谈工具对抑郁症进行评估,旨在确定抑郁症的诊断并将其与其他精神疾病区分开来:结果:有抑郁症状的 2 型糖尿病患者的 BDNF 水平明显低于无抑郁症状的 2 型糖尿病患者(82.6±16.1 Vs 122±17.47,p˂ 0.001)。糖尿病患者的 BDNF 水平在 BDNF 基因的三种基因型之间存在显著的统计学差异(p 值 < 0.001)。Val/Val基因携带者的血清BDNF水平最高,而Met/Met基因携带者的血清BDNF水平最低。亚组分析显示,抑郁组中三个亚组的血清 BDNF 水平在统计学上存在显著的基因型相关差异。Val/Val携带者的血清BDNF水平最高,Met/Met携带者的血清BDNF水平最低。BDNF Val66Met 多态性与是否患有抑郁症无明显关联,但有显著性趋势(p = 0.05):在这项试验中,2 型糖尿病患者的 BDNF 水平低与抑郁有关。Met/Met等位基因携带者的血清BDNF水平最低。需要对更多参与者进行多中心研究。
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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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