Role of E-cadherin and β-catenin in head and neck squamous cell carcinoma

Q4 Medicine
A. A. Petrova, S. Samoylova, L. V. Magomedkerimova, S. A. Parts, I. V. Reshetov
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引用次数: 0

Abstract

Aim of the study: to present and summarize current data on the prognostic value of E-cadherin and β-catenin markers for head and neck squamous cell carcinoma, as well as to substantiate the potential benefit from implementing research results into clinical practice within the framework of a personalized approach to the treatment of head and neck squamous cell carcinoma.Material and Methods. We performed a literature search and review in Pubmed, Scopus, Google Scholar and RSCI databases regarding the association of the level of E-cadherin and β-catenin markers with disease prognosis, aggressiveness of tumor behavior and response to treatment.Results. Detailed information on the functions and mechanisms of E-cadherin and β-catenin proteins were presented and pathogenetic pathways involved in epithelial-mesenchymal transition were described. The results of studies on the association of β-catenin and E-cadherin expression levels with the prognosis of head and neck squamous cell carcinoma are collected and summarized. High expression levels of β-catenin and E-cadherin are associated with lymph node metastasis, poor prognosis and poor response to treatment.Conclusion. The expression levels of β-catenin and E-cadherin correlate with tumor invasion and lymph node metastasis, thus suggesting that β-catenin and E-cadherin can be used as potential markers of prognosis and treatment response in patients with head and neck squamous cell carcinoma. Further studies are needed to evaluate the co-expression of E-cadherin, β-catenin and other squamous cell carcinoma-associated markers, their impact on prognosis and treatment response, as well as their prognostic value.
E 黏附因子和β-catenin在头颈部鳞状细胞癌中的作用
研究目的:介绍和总结有关头颈部鳞状细胞癌E-cadherin和β-catenin标记物预后价值的现有数据,并证实在头颈部鳞状细胞癌个性化治疗方法框架内将研究成果应用于临床实践的潜在益处。我们在Pubmed、Scopus、Google Scholar和RSCI数据库中对E-cadherin和β-catenin标记物水平与疾病预后、肿瘤行为的侵袭性和治疗反应的相关性进行了文献检索和综述。详细介绍了E-cadherin和β-catenin蛋白的功能和机制,并描述了上皮-间质转化过程中的致病途径。收集并总结了β-catenin和E-cadherin表达水平与头颈部鳞状细胞癌预后相关性的研究结果。结论:β-catenin和E-cadherin的高表达水平与淋巴结转移、预后不良和治疗反应差有关。β-catenin和E-cadherin的表达水平与肿瘤侵袭和淋巴结转移相关,因此提示β-catenin和E-cadherin可作为头颈部鳞状细胞癌患者预后和治疗反应的潜在标志物。还需要进一步的研究来评估E-cadherin、β-catenin和其他鳞状细胞癌相关标记物的共同表达、它们对预后和治疗反应的影响及其预后价值。
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来源期刊
Siberian journal of oncology
Siberian journal of oncology Medicine-Oncology
CiteScore
0.40
自引率
0.00%
发文量
117
审稿时长
8 weeks
期刊介绍: The main objectives of the journal are: -to promote the establishment of Russia’s leading worldwide positions in the field of experimental and clinical oncology- to create the international discussion platform intended to cover all aspects of basic and clinical cancer research, including carcinogenesis, molecular biology, epidemiology, cancer prevention, diagnosis and multimodality treatment (surgery, chemotherapy, radiation therapy, hormone therapy), anesthetic management, medical and social rehabilitation, palliative care as well as the improvement of life quality of cancer patients- to encourage promising young scientists to be actively involved in cancer research programs- to provide a platform for researches and doctors all over the world to promote, share, and discuss various new issues and developments in cancer related problems. (to create a communication platform for the expansion of cooperation between Russian and foreign professional associations).- to provide the information about the latest worldwide achievements in different fields of oncology The most important tasks of the journal are: -to encourage scientists to publish their research results- to offer a forum for active discussion on topics of major interest - to invite the most prominent Russian and foreign authors to share their latest research findings with cancer research community- to promote the exchange of research information, clinical experience, current trends and the recent developments in the field of oncology as well as to review interesting cases encountered by colleagues all over the world- to expand the editorial board and reviewers with the involvement of well-known Russian and foreign experts- to provide open access to full text articles- to include the journal into the international database- to increase the journal’s impact factor- to promote the journal to the International and Russian markets
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