Screening of Coconut (Cocos nucifera Linn.) Shell for its Bioactive Secondary Metabolites and Analogous Pharmacotherapeutic Prospective

V. Sreekala, Kamal Nayan Dwivedi, R. Rajesh
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Abstract

Coconut shell is an inexpensive, easily available, and usually discarded material from the plant source Cocos nucifera Linn. belonging to the Arecaceae family. The internal administration of water boiled with endocarp of coconut fruit (coconut shell) is used as a folklore remedy in Kerala for treating metabolic disorders. This folklore claim has to be scientifically validated by comprehensive chemical profiling of coconut (Cocos nucifera Linn.) shell. The present study was designed to conduct a systematic screening of coconut shell for identification of its bioactive secondary metabolites and validation of its analogous pharmacotherapeutic potentials. The present research work is focused on the screening of dried ripe coconut (Cocos nucifera Linn.) shell for its bioactive secondary metabolites based on microscopic, histochemical, and phytochemical studies. Characteristic presence of thin-walled fibers and fibrosclereids were observed in the powder microscopy of coconut shell. Histochemical studies were suggestive of the presence of lignified cells and tannins in the test drug. Further phytochemical studies of Cocos nucifera Linn. ascertained that the endocarp is abounded with diverse bioactive phytoconstituents like flavonoids, alkaloids, phenols, steroids, tannins, and saponins which possess varied antioxidant, anti-inflammatory, anti-obesity, and antidiabetic activities. The study outcome suggests coconut shell as a novel natural source of various bioactive secondary metabolites and these findings can be integrated for further researches exploring the comprehensive pharmacotherapeutic prospective of the test drug.
椰子(Cocos nucifera Linn.)
椰子壳是一种价格低廉、容易获得、通常被丢弃的材料,其植物来源是属于 Arecaceae 科的 Cocos nucifera Linn.。在喀拉拉邦,用椰子果实内果皮(椰子壳)煮水内服是治疗代谢紊乱的一种民间疗法。这一民间传说必须通过对椰子(Cocos nucifera Linn.) 本研究旨在对椰子壳进行系统筛选,以鉴定其生物活性次生代谢物,并验证其类似的药物治疗潜力。 本研究工作的重点是在显微镜、组织化学和植物化学研究的基础上,筛选干熟椰子(Cocos nucifera Linn.) 在椰子壳的粉末显微镜下观察到了薄壁纤维和纤维索的特征性存在。组织化学研究表明,试验药物中存在木质化细胞和单宁酸。进一步的植物化学研究表明,椰子内果皮富含多种具有生物活性的植物成分,如黄酮类、生物碱、酚类、类固醇、单宁和皂苷,它们具有不同的抗氧化、抗炎、抗肥胖和抗糖尿病活性。 研究结果表明,椰子壳是各种生物活性次生代谢物的新型天然来源,这些发现可用于进一步研究,探索试验药物的综合药物治疗前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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