The D-SPECT SH reconstruction protocol: improved quantification of small left ventricle volumes.

IF 3 2区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

EJNMMI Physics Pub Date : 2024-01-08 DOI:10.1186/s40658-023-00606-y

Yan Huang, Han Zhang, Xueping Hu, Shanshan Qin, Fan Hu, Yuchen Li, Haidong Cai, Kuangyu Shi, Fei Yu

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引用次数: 0

Abstract

Background: Due to spatial resolution limitations, conventional NaI-SPECT typically overestimates the left ventricular (LV) ejection fraction (EF) in patients with small LV volumes. The purpose of this study was to explore the clinical application value of the small heart (SH) reconstruction protocol embedded in the postprocessing procedure of D-SPECT.

Methods: We retrospectively analyzed patients who undergo both D-SPECT and echocardiography (Echo) within one week. Patients with small LV volume were defined as those with a rest end-systolic volume (rESV) ≤ 25 mL and underwent reconstruction using the standard (SD) reconstruction protocol. The SH protocol was deemed successful in correcting the LVEF value if it decreased by 5% or more compared to the SD protocol. The ROC curve was used to calculate the optimal cutoff value of the SH protocol. LVEF, ESV and EDV were computed with SD and SH, respectively. Echo was performed as a reference, and Echo-LVEF, ESV, and EDV were calculated using the Teichholz formula. One-way ANOVA was used to compare these parameters among the three groups.

Results: The final study included 209 patients (73.21% female, age 67.34 ± 7.85 years). Compared with the SD protocol, the SH protocol significantly decreased LVEF (67.43 ± 7.38% vs. 71.30 ± 7.61%, p < 0.001). The optimal cutoff value for using the SH protocol was rESV > 17 mL (AUC = 0.651, sensitivity = 78.43%, specificity = 45.57%, p = 0.001). In the subgroup of rESV > 17 mL, there was no significant difference in LVEF (61.84 ± 4.67% vs. 62.83 ± 2.85%, p = 0.481) between the SH protocol and Echo, and no significant difference was observed in rESV (26.92 ± 3.25 mL vs. 27.94 ± 7.96 mL, p = 0.60) between the SH protocol and Echo.

Conclusion: This pilot study demonstrated that the SH reconstruction protocol was able to effectively correct the overestimation of LVEF in patients with small LV volumes. Particularly, in the rESV > 17 mL subgroup, the time and computing power waste could be reduced while still ensuring the accuracy of the LVEF value and image quality.

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D-SPECT SH 重建方案：改进了小左心室容积的量化。

背景：由于空间分辨率的限制，传统的NaI-SPECT通常会高估左心室容积较小患者的左心室射血分数（EF）。本研究旨在探讨 D-SPECT 后处理程序中嵌入的小心脏（SH）重建方案的临床应用价值：我们对一周内同时接受 D-SPECT 和超声心动图（Echo）检查的患者进行了回顾性分析。左心室容积过小的患者被定义为静息期收缩末期容积（rESV）≤ 25 mL，并使用标准（SD）重建方案进行重建。如果LVEF值比SD重建方案降低了5%或更多，则认为SH重建方案成功校正了LVEF值。ROC 曲线用于计算 SH 方案的最佳临界值。LVEF、ESV和EDV分别用SD和SH计算。以回波为参考，使用 Teichholz 公式计算回波-LVEF、ESV 和 EDV。采用单因素方差分析比较三组患者的这些参数：最终研究纳入了 209 名患者（73.21% 为女性，年龄为 67.34 ± 7.85 岁）。与 SD 方案相比，SH 方案显著降低了 LVEF（67.43 ± 7.38% vs. 71.30 ± 7.61%，p 17 mL，AUC = 0.651，敏感性 = 78.43%，特异性 = 45.57%，p = 0.001）。在 rESV > 17 mL 的亚组中，SH 方案和 Echo 方案的 LVEF（61.84 ± 4.67% vs. 62.83 ± 2.85%，p = 0.481）无显著差异，SH 方案和 Echo 方案的 rESV（26.92 ± 3.25 mL vs. 27.94 ± 7.96 mL，p = 0.60）也无显著差异：这项试验研究表明，SH 重建方案能有效纠正小左心室容积患者 LVEF 被高估的情况。特别是在 rESV > 17 mL 亚组中，在确保 LVEF 值准确性和图像质量的同时，还能减少时间和计算能力的浪费。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

EJNMMI Physics Physics and Astronomy-Radiation

CiteScore

6.70

自引率

10.00%

发文量

审稿时长

13 weeks

期刊介绍： EJNMMI Physics is an international platform for scientists, users and adopters of nuclear medicine with a particular interest in physics matters. As a companion journal to the European Journal of Nuclear Medicine and Molecular Imaging, this journal has a multi-disciplinary approach and welcomes original materials and studies with a focus on applied physics and mathematics as well as imaging systems engineering and prototyping in nuclear medicine. This includes physics-driven approaches or algorithms supported by physics that foster early clinical adoption of nuclear medicine imaging and therapy.