CLERODENDRUM INFORTUNATUM ATTENUATES PANCREATIC OXIDATIVE STRESS AND DYSREGULATED CARBOHYDRATE METABOLISM IN STREPTOZOTOCIN-INDUCED EXPERIMENTAL DIABETES

International Journal of Pharmaceutical Sciences and Drug Research Pub Date : 2023-06-30 DOI:10.25004/ijpsdr.2023.150302

Jyothi S. Pillai, Padmakumaran Nair K G, Nandakumar S, Robin J. Thomson, Saumya S Pillai

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Abstract

The prevalence of diabetes mellitus is increasing at an alarming rate and is gravely troubling human health and quality of life. Side effects of synthetic hypoglycemic agents have led to investigations on alternative sources such as herbal drugs in treating diabetes. Anti-diabetic properties of Clerodendrum infortunatum in streptozotocin-induced experimental diabetes were evaluated and compared with the standard anti-diabetic drug glibenclamide. Aqueous extract of C. infortunatum on carbohydrate metabolism revealed its hypoglycemic effect in diabetic conditions. Furthermore, it could significantly modulate insulin secretion, glycolysis, gluconeogenesis and glycogen metabolism for effective glucose homeostasis. Notably, the drug could accelerate the activities of major antioxidant enzymes and reduce the content of lipid peroxidation products in the pancreas. The study proves the efficacy of C. infortunatum as a potent source of phytochemicals in ameliorating diabetic complications and suggests the medicinal plant as a nutraceutical agent.

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减轻链脲佐菌素诱导的实验性糖尿病的胰腺氧化应激和碳水化合物代谢紊乱

糖尿病的发病率正以惊人的速度增长，严重困扰着人类的健康和生活质量。合成降糖药的副作用促使人们研究治疗糖尿病的替代药物，如草药。研究人员评估了红花檵木在链脲佐菌素诱导的实验性糖尿病中的抗糖尿病特性，并将其与标准抗糖尿病药物格列本脲进行了比较。结果表明，红花檵木水提取物对糖尿病患者的碳水化合物代谢具有降血糖作用。此外，它还能明显调节胰岛素分泌、糖酵解、糖生成和糖原代谢，从而有效地实现血糖平衡。值得注意的是，该药物能加速主要抗氧化酶的活性，降低胰腺中脂质过氧化产物的含量。这项研究证明了红豆杉作为一种有效的植物化学物质来源在改善糖尿病并发症方面的功效，并建议将这种药用植物作为一种营养保健品。

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International Journal of Pharmaceutical Sciences and Drug Research

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