Implant tuberculosis: A rare but possible cause in nonhealing surgical wound!

S. Patil, D. Patil, Shubhangi Khule
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Abstract

Tuberculosis is most commonly involving lungs and less than 20% cases were showing extrapulmonary involvement. Tuberculosis at surgical site is described in medical literature with very few cases in caesarean section surgical incision site. Implant tuberculosis is first time described in literature and is defined as “tuberculosis developed after implantation of mycobacterium tuberculosis bacilli by artificial means without involvement of primary organ or secondary lymphatic and/or hematogenous dissemination.” Caesarean section delivery is a common method of delivery of baby. Surgical site infections resulting to slowly healing to nonhealing wound are commonly reported and usually depend on various factors. Patient factors are immune status and comorbidities of patient. Hospital management factors such as operation theatre infection control policies, sterilization techniques for surgical instruments, and local wound care methods are established and implemented by hospital staff. In this case report, a 34-year-old female with history of caesarean delivery 1 month back presented with nonhealing wound at surgical site. We have done surgical repair with biopsy of wound margins. Wound discharge microscopy was negative for acid fast bacilli with few Gram-positive cocci. Cartridge-based nucleic acid amplification testes were positive for mycobacterium tuberculosis genome. Histopathology shows tuberculous pathology and underlying chronic infectious process for nonhealing wound. We have offered antituberculosis treatment (ATT) as per protocol and observed healing of tuberculous ulcer after 3 months with reappearance of ulcer in the 4th month of ATT. We have topically applied isoniazid and streptomycin over tuberculous ulcer along with systemic ATT. Tuberculous ulcer has responded and noted “cure” as completely healed surgical wound after 6 months of ATT.
植入物结核病:手术伤口不愈合的一个罕见但可能的原因!
肺结核最常累及肺部,只有不到 20% 的病例显示肺外受累。医学文献中对手术部位结核病的描述很少涉及剖腹产手术切口部位。植入性结核病是首次在文献中描述,其定义为 "通过人工方法植入结核分枝杆菌后发生的结核病,但未累及原发器官或继发淋巴和/或血行播散"。剖腹产是一种常见的分娩方式。手术部位感染导致伤口愈合缓慢或不愈合的报道屡见不鲜,通常取决于各种因素。患者因素包括患者的免疫状况和合并症。医院管理因素包括手术室感染控制政策、手术器械消毒技术以及医院员工制定和实施的局部伤口护理方法。在本病例报告中,一名 34 岁的女性患者在 1 个月前曾做过剖腹产手术,手术部位伤口不愈合。我们进行了手术修复,并对伤口边缘进行了活检。伤口分泌物显微镜检查显示酸性快速杆菌阴性,有少量革兰氏阳性球菌。盒式核酸扩增检测结果显示结核分枝杆菌基因组阳性。组织病理学显示,伤口不愈合的原因是结核病变和潜在的慢性感染过程。我们按照方案提供了抗结核治疗(ATT),观察到结核性溃疡在 3 个月后愈合,但在 ATT 的第 4 个月溃疡再次出现。在全身 ATT 的同时,我们还在结核性溃疡上局部使用了异烟肼和链霉素。经过 6 个月的 ATT 治疗后,结核性溃疡已经痊愈,手术伤口完全愈合。
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20 weeks
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